Department of Biochemistry, Federal University of Technology Owerri, Nigeria.
Department of Biotechnology, Federal University of Technology Owerri, Nigeria.
Afr Health Sci. 2022 Mar;22(1):418-430. doi: 10.4314/ahs.v22i1.51.
Human immunodeficiency virus (HIV) and hepatitis B virus (HBV) are currently two important blood-borne human pathogens of major public health concern with high prevalence rates in Africa.
The study assessed the impact of HIV and HBV mono- and co-infections on serum total protein, albumin, globulin fractions and plasma free amino acids concentrations.
This was a cross-sectional study on adult (25 - 64 years old) patients on Highly Active Antiretroviral Therapy attending AIDS Preventive Initiative in Nigeria Centre, Jos University Teaching Hospital, Plateau State, Nigeria. It involved 80 subjects; 20 HIV/HBV co-infected, 20 each of HIV and HBV mono-infected controls, and 20 seronegative controls.
Significant (p<0.05) increases in total protein and gamma globulin but a reduction in albumin concentrations were observed in the HIV/HBV co-infected group. Similarly, significant (p<0.05) increases in alpha-1 and alpha-2 globulin concentrations were observed in the mono- and co-infected groups compared to the seronegative control group. There were significant (p<0.05) increases in the glucogenic, aromatic and branched-chain amino acid concentrations of the HIV/HBV co-infected subjects.
The study suggests prognostic importance of alpha and gamma globulin fractions of serum protein as well as amino acid profile in the management of HIV/HBV co-infection.
人类免疫缺陷病毒（HIV）和乙型肝炎病毒（HBV）是目前两种重要的血源性人类病原体，在非洲具有较高的流行率，引起了主要的公共卫生关注。
本研究评估了 HIV 和 HBV 单一和合并感染对血清总蛋白、白蛋白、球蛋白分数和血浆游离氨基酸浓度的影响。
这是一项在尼日利亚乔斯大学教学医院艾滋病预防倡议中心接受高效抗逆转录病毒治疗的成年（25-64 岁）患者的横断面研究。共纳入 80 例患者，包括 20 例 HIV/HBV 合并感染、20 例 HIV 单感染对照和 20 例 HBV 单感染对照以及 20 例血清阴性对照。
HIV/HBV 合并感染组的总蛋白和γ球蛋白显著升高（p<0.05），而白蛋白浓度降低。同样，与血清阴性对照组相比，单一和合并感染组的α-1 和 α-2 球蛋白浓度也显著升高（p<0.05）。HIV/HBV 合并感染组的糖生成、芳香族和支链氨基酸浓度显著升高（p<0.05）。
本研究表明，血清蛋白的α和γ球蛋白分数以及氨基酸谱在 HIV/HBV 合并感染的管理中具有预后意义。
