慢性乙型肝炎病毒无症状携带者中丁型肝炎病毒抗体的流行率及危险因素：一项社区调查。
Prevalence and risk factors of Hepatitis D virus antibody among asymptomatic carriers of Hepatitis B virus: a community survey.
机构信息
Gastroenterology/Hepatology Unit, Department of Internal Medicine.
Department of Chemical pathology.
出版信息
Afr Health Sci. 2022 Mar;22(1):504-510. doi: 10.4314/ahs.v22i1.59.
BACKGROUND
Hepatitis D virus (HDV) can cause a chronic infection in the presence of hepatitis B surface antigen and contribute to the burden of chronic liver disease especially in regions where chronic hepatitis B virus (HBV) infection is endemic.
AIM
To determine the prevalence and risk factors of HDV among asymptomatic carriers of HBsAg in Cross River State, Nigeria.
METHODS
This was a cross-sectional study conducted among apparently healthy adults resident in Cross River State, Nigeria. A structured questionnaire was used to collect socio-demograhic data and risk factors for HBV/HDV infection. Participants blood samples were screened for HBsAg. Samples that were HBsAg positive were further screened for anti-HDVIgM. Statistical analysis was performed using statistical package for social sciences (SPSS) version 20.
RESULTS
A total of 90 HBsAg positive samples were assayed. The prevalence of anti-HDV IgM was 5.6% (95% CI 1.1-10.1). The HDV positive subjects were mostly females (80%), reported family size of >5 members (80%), had female circumcision (75%) and took injections from Non-certified health care practitioners (NCHCPs). None of the assessed risk factors were significantly associated with HDV infection (p >0.05).
CONCLUSION
Hepatitis D virus is moderately prevalent amongst asymptomatic HBsAg carriers in Cross River State, Nigeria.
背景
丁型肝炎病毒（HDV）可在乙型肝炎表面抗原存在的情况下引起慢性感染，并导致慢性肝病的负担加重，尤其是在乙型肝炎病毒（HBV）感染流行的地区。
目的
在尼日利亚十字河州，确定无症状 HBsAg 携带者中 HDV 的流行率和危险因素。
方法
这是一项在尼日利亚十字河州居住的貌似健康成年人中进行的横断面研究。使用结构化问卷收集社会人口统计学数据和 HBV/HDV 感染的危险因素。采集参与者的血液样本筛查 HBsAg。HBsAg 阳性的样本进一步筛查抗-HDVIgM。使用社会科学统计软件包（SPSS）版本 20 进行统计分析。
结果
共检测了 90 份 HBsAg 阳性样本。抗-HDV IgM 的流行率为 5.6%（95%CI 1.1-10.1）。HDV 阳性的受试者主要是女性（80%），报告家庭人数>5 人（80%），有女性割礼（75%），并从非认证的医疗保健从业者（NCHCP）处接受注射。评估的危险因素均与 HDV 感染无显著相关性（p>0.05）。
结论
在尼日利亚十字河州，无症状 HBsAg 携带者中丁型肝炎病毒的流行率中等。
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