• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

卡马西平诱发的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）在一位 HLA-A*31:01 阳性、服用多种药物的患者中的药物基因组学检测确认

Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient.

作者信息

Speicher Leigh, Crosby Sheena, Schuh Michael J

机构信息

General Internal Medicine, Mayo Clinic Florida; Contribution: writing, clinical resource.

Ambulatory Pharmacist, Mayo Clinic Florida; Contribution: writing, review.

出版信息

Innov Pharm. 2021 Sep 22;12(4). doi: 10.24926/iip.v12i4.4341. eCollection 2021.

DOI:10.24926/iip.v12i4.4341
PMID:36033112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9401381/
Abstract

Pharmacogenomics (PGx) melds well with polypharmacy as another tool to identify medication related problems (MRPs) more specifically so they may be solved most effectively. PGx can pre-emptively assist in medication selection, medication dosing or identify better medications for patients already taking a medication. PGx can also confirm suspect medications of causing MRPs such as adverse drug reactions (ADRs) or drug interactions. In this case, PGx testing confirmed presence of a serious human leukocyte antigen (HLA) drug reaction with eosinophilia and systemic symptoms (DRESS) after a suspect medication had been stopped.

摘要

药物基因组学（PGx）与多药治疗配合良好，作为另一种工具可更具体地识别与药物相关的问题（MRP），以便能最有效地解决这些问题。PGx可以在用药选择、药物剂量确定方面提供前瞻性帮助，或者为已经在服用某种药物的患者确定更合适的药物。PGx还可以确认导致MRP的可疑药物，如药物不良反应（ADR）或药物相互作用。在本案例中，在停用一种可疑药物后，PGx检测证实存在伴有嗜酸性粒细胞增多和全身症状的严重人类白细胞抗原（HLA）药物反应（DRESS）。

相似文献

1
Pharmacogenomics Testing Confirmation of Carbamazepine Induced DRESS Reaction of an HLA-A*31:01 Positive, Polypharmacy Patient.卡马西平诱发的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）在一位 HLA-A*31:01 阳性、服用多种药物的患者中的药物基因组学检测确认
Innov Pharm. 2021 Sep 22;12(4). doi: 10.24926/iip.v12i4.4341. eCollection 2021.
2
Chronic Anticholinergic Toxicity Discovered in a Pharmacogenomics, Polypharmacy Patient.在一名药物基因组学、联合用药患者中发现慢性抗胆碱能毒性。
Sr Care Pharm. 2021 Jun 1;36(6):304-310. doi: 10.4140/TCP.n.2021.304.
3
Polypharmacy as Formal Training and a Model of Practice.药物滥用作为正式培训和实践模式。
Sr Care Pharm. 2024 May 1;39(5):173-177. doi: 10.4140/TCP.n.2024.173.
4
Medication Optimization Using Pharmacogenomic Testing in a Complex Mental Health Population Prescribed Psychiatric Polypharmacy.在精神卫生人群中开具精神科药物的情况下，使用药物基因组学检测实现药物优化。
J Clin Pharmacol. 2022 Jul;62(7):898-904. doi: 10.1002/jcph.2032. Epub 2022 Mar 4.
5
Calculation of the pharmacogenomics benefit score for patients with medication-related problems.药物相关问题患者的药物基因组学获益评分计算
Front Genet. 2023 May 5;14:1152585. doi: 10.3389/fgene.2023.1152585. eCollection 2023.
6
Evolution of Pharmacogenomics and the Importance of PGx Data Integration in Health Care System: A 10 Years Retrospective Study in Thailand.泰国药物基因组学的发展及药物基因组学数据整合在医疗保健系统中的重要性：一项为期10年的回顾性研究
Front Pharmacol. 2022 Apr 5;13:866903. doi: 10.3389/fphar.2022.866903. eCollection 2022.
7
Pharmacogenomics (PGx) Patient with Mixed Levels of Actionable Variant Evidence.具有不同程度可操作变异证据的药物基因组学（PGx）患者。
Innov Pharm. 2020 Apr 30;11(2). doi: 10.24926/iip.v11i2.3228. eCollection 2020.
8
Additional Utility of Pharmacogenomics (PGx) Panel Testing in a CYP2D6 Normal Metabolizer with a History of Breast Cancer.药物基因组学（PGx）检测在有乳腺癌病史的CYP2D6正常代谢者中的额外效用
Innov Pharm. 2019 Jul 18;10(3). doi: 10.24926/iip.v10i3.2013. eCollection 2019.
9
Drug Use among Nursing Home Residents in Denmark for Drugs Having Pharmacogenomics Based (PGx) Dosing Guidelines: Potential for Preemptive PGx Testing.丹麦养老院居民中依据药物基因组学（PGx）给药指南使用药物的情况：进行预防性PGx检测的可能性
J Pers Med. 2020 Jul 31;10(3):78. doi: 10.3390/jpm10030078.
10
HLA-A*31:01 and carbamazepine-induced DRESS syndrom in a sample of North African population.HLA-A*31:01 与卡马西平诱导的北非人群中的 DRESS 综合征。
Seizure. 2017 Dec;53:42-46. doi: 10.1016/j.seizure.2017.10.018. Epub 2017 Oct 27.

引用本文的文献

1
High-Evidence, Actionable Phenotype Gene Distribution in a Multispecialty, Tertiary Care Clinic: Potentially Actionable Genes and a Referring Department Profile.多专科三级护理诊所中高证据、可操作表型基因分布：潜在可操作基因及转诊科室概况
Innov Pharm. 2023 Oct 10;14(2). doi: 10.24926/iip.v14i2.5476. eCollection 2023.

本文引用的文献

1
Drug reaction with eosinophilia and systemic symptoms may occur within 2 weeks of drug exposure: A retrospective study.药物反应伴嗜酸性粒细胞增多和全身症状可能在药物暴露后 2 周内发生：一项回顾性研究。
J Am Acad Dermatol. 2020 Mar;82(3):606-611. doi: 10.1016/j.jaad.2019.09.036. Epub 2019 Sep 25.
2
Pharmacogenomic Approaches for Automated Medication Risk Assessment in People with Polypharmacy.多药联用人群自动药物风险评估的药物基因组学方法
AMIA Jt Summits Transl Sci Proc. 2018 May 18;2017:142-151. eCollection 2018.
3
Drug Reaction with Eosinophilia and Systemic Symptoms: An Update and Review of Recent Literature.药物超敏反应伴嗜酸性粒细胞增多和全身症状：近期文献综述与更新
Indian J Dermatol. 2018 Jan-Feb;63(1):30-40. doi: 10.4103/ijd.IJD_582_17.
4
What is polypharmacy? A systematic review of definitions.什么是多重用药？定义的系统综述。
BMC Geriatr. 2017 Oct 10;17(1):230. doi: 10.1186/s12877-017-0621-2.
5
The allele: influence on carbamazepine treatment.该等位基因：对卡马西平治疗的影响。
Pharmgenomics Pers Med. 2017 Jan 31;10:29-38. doi: 10.2147/PGPM.S108598. eCollection 2017.
6
Potential utility of precision medicine for older adults with polypharmacy: a case series study.精准医学对老年多重用药患者的潜在效用：一项病例系列研究。
Pharmgenomics Pers Med. 2016 Apr 15;9:31-45. doi: 10.2147/PGPM.S101474. eCollection 2016.
7
HLA-A*31:01 and different types of carbamazepine-induced severe cutaneous adverse reactions: an international study and meta-analysis.HLA-A*31:01 与不同类型卡马西平诱导的严重皮肤不良反应：一项国际研究和荟萃分析。
Pharmacogenomics J. 2014 Jun;14(3):281-8. doi: 10.1038/tpj.2013.40. Epub 2013 Dec 10.
8
Clinical consequences of polypharmacy in elderly.老年人药物过多的临床后果。
Expert Opin Drug Saf. 2014 Jan;13(1):57-65. doi: 10.1517/14740338.2013.827660. Epub 2013 Sep 27.
9
Pharmacogenomics knowledge for personalized medicine.药物基因组学知识与个性化医疗。
Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96.
10
Reducing cost by reducing polypharmacy: the polypharmacy outcomes project.通过减少多种用药来降低成本：多种用药结果项目。
J Am Med Dir Assoc. 2012 Nov;13(9):818.e11-5. doi: 10.1016/j.jamda.2012.07.019. Epub 2012 Sep 5.