Liang Song, Yin Xiao, Fu Yu, Li Xinglin, Zhu Junchao, Xu Ran
Department of Thoracic Surgery, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
Biomed Res Int. 2022 Jul 30;2022:3240252. doi: 10.1155/2022/3240252. eCollection 2022.
Thoracoscopic minimally invasive surgery is the main method for the treatment of lung cancer. The reduction of surgical trauma can effectively reduce the intraoperative and postoperative inflammatory reaction. The aim of the study is to compare the intraoperative and postoperative inflammatory reactions in patients with non-small-cell lung cancer (NSCLC) treated by single-port thoracoscopic surgery and three-port thoracoscopic surgery.
A total of 68 NSCLC patients (stages I and II) of thoracoscopic surgery were selected and randomly divided into two groups where they received either single-port thoracoscopic surgery or three-port thoracoscopic surgery. Intraoperative and postoperative serum inflammatory markers (C-reactive protein, CRP; serum amyloid A protein, SAA; and interleukin 6, IL-6) were detected using the enzyme-linked immunosorbent assay.
The CRP level of the single-port group was significantly lower than that of the three-port group during surgery, the first day after surgery, and third day after surgery ( < 0.05). The level of IL-6 in the single-port group was significantly lower than that in the three-port group during surgery on the first and third days after surgery ( < 0.05). The level of SAA in the single-port group was also significantly lower than that in the three-port group on the first and third days after surgery ( < 0.05).
Compared with three-port thoracoscopic surgery, single-port thoracoscopic surgery could reduce the inflammatory response and improve the recovery of NSCLC patients. Single-port thoracoscopic surgery is worthy of further promotion in the current treatment field of NSCLC in terms of reducing intraoperative and postoperative inflammatory reactions.
胸腔镜微创手术是治疗肺癌的主要方法。手术创伤的减少可有效减轻术中和术后的炎症反应。本研究旨在比较单孔胸腔镜手术和三孔胸腔镜手术治疗非小细胞肺癌（NSCLC）患者的术中和术后炎症反应。
选取68例接受胸腔镜手术的NSCLC患者（Ⅰ期和Ⅱ期），随机分为两组，分别接受单孔胸腔镜手术或三孔胸腔镜手术。采用酶联免疫吸附测定法检测术中和术后血清炎症标志物（C反应蛋白，CRP；血清淀粉样蛋白A，SAA；白细胞介素6，IL-6）。
单孔组在手术期间、术后第1天和术后第3天的CRP水平显著低于三孔组（<0.05）。单孔组在手术期间、术后第1天和第3天的IL-6水平显著低于三孔组（<0.05）。单孔组在术后第1天和第3天的SAA水平也显著低于三孔组（<0.05）。
与三孔胸腔镜手术相比，单孔胸腔镜手术可减轻炎症反应，促进NSCLC患者的恢复。就减轻术中和术后炎症反应而言，单孔胸腔镜手术在当前NSCLC治疗领域值得进一步推广。
