Lu Wang Feng, Liu Lei, Zhang Yong Hong, Liu Huanxian
Department of Gastrointestinal Surgery, Shangluo Central Hospital, Shanxi, China.
Department of Neurology, First Medical Center of Chinese PLA General Hospital, Beijing, China.
J Clin Gastroenterol. 2024 Aug 14. doi: 10.1097/MCG.0000000000002060.
To investigate the potential association between Dietary Inflammatory Index (DII) scores and constipation among a sample of adults in the United States.
This cross-sectional study used data from adult participants in the 2005 to 2010 National Health and Nutrition Examination Survey (ie, "NHANES"). Self-reported information was used to identify cases of constipation. The DII was used to assess inflammatory potential of the diet. Odds ratios (ORs) and corresponding 95% CIs for the association between the DII and constipation were determined using multivariate logistic regression modeling. Stratified analyses explored whether there was effect modification to influence the relationship between DII and constipation.
Of 8272 subjects, 759 reported constipation, and 7513 did not, corresponding to a prevalence of 9.2%. After adjusting for age, gender, race/ethnicity, marital status, education level, smoking status, alcohol consumption, physical activity, body mass index (BMI), cardiovascular diseases (CVD), hypertension, stroke, diabetes, energy intake, carbohydrate intake, and selective serotonin reuptake inhibitor (SSRI) use. Compared with lower DII scores group T1 (-5.28 to ≤0.72), the adjusted OR values for DII scores and constipation in T2 (>0.72 to ≤2.50) and T3 (>2.50 to 5.24) were 1.27 (95% CI: 1.02-1.58, P=0.029) and 1.43(95% CI: 1.14-1.8, P=0.002). Subgroup analyses showed that there were effect modification of gender and physical activity factors on DII scores and constipation.
Results of this cross-sectional study suggest that a higher dietary inflammatory index score was associated with increased risk of constipation after adjustment for confounding in a multivariable analysis. gender and physical activity were found to be an effect modifier of this relationship.
调查美国成年人样本中饮食炎症指数（DII）得分与便秘之间的潜在关联。
这项横断面研究使用了2005年至2010年国家健康与营养检查调查（即“NHANES”）中成年参与者的数据。自我报告信息用于确定便秘病例。DII用于评估饮食的炎症潜力。使用多变量逻辑回归模型确定DII与便秘之间关联的比值比（OR）及相应的95%置信区间（CI）。分层分析探讨是否存在效应修饰以影响DII与便秘之间的关系。
在8272名受试者中，759人报告有便秘，7513人没有，患病率为9.2%。在调整年龄、性别、种族/民族、婚姻状况、教育水平、吸烟状况、饮酒、身体活动、体重指数（BMI）、心血管疾病（CVD）、高血压、中风、糖尿病、能量摄入、碳水化合物摄入以及选择性5-羟色胺再摄取抑制剂（SSRI）使用情况后。与较低DII得分组T1（-5.28至≤0.72）相比，T2（>0.72至≤2.50）和T3（>2.50至5.24）中DII得分与便秘的调整后OR值分别为1.27（95%CI：1.02-1.58，P=0.029）和1.43（95%CI：1.14-1.8，P=0.002）。亚组分析表明，性别和身体活动因素对DII得分与便秘存在效应修饰。
这项横断面研究结果表明，在多变量分析中调整混杂因素后，较高的饮食炎症指数得分与便秘风险增加相关。性别和身体活动被发现是这种关系的效应修饰因素。
