Key Laboratory of Tumor Immunology and Microenvironmental Regulation of Guangxi, Guilin Medical University, Guilin, China.
Guangxi Health Commission Key Laboratory of Tumor Immunology and Receptor-Targeted Drug Basic Research, Guilin Medical University, Guilin, China.
Front Endocrinol (Lausanne). 2022 Aug 11;13:949228. doi: 10.3389/fendo.2022.949228. eCollection 2022.
As we all know, female obesity has become a global epidemic, which is usually accompanied with endocrine and metabolic disorders. Obese women are more likely to experience reproductive problems, including infertility, embryonic developmental defects and abnormality in offspring. Female obesity is a complex multifactorial condition, where there are many mechanisms involved in the effects of overweight and obesity on the development of these reproductive disorders. The insulin resistance, hyperinsulinaemia and hyperandrogenism, lipotoxicity and inflammation are important mechanisms. However, the precise mechanism concerning their correlation is still unclear. Fortunately, weight loss methods have been found to reverse the effects of maternal obesity on the fertility, fetus and offspring.
众所周知，女性肥胖已成为全球性的流行病，通常伴随着内分泌和代谢紊乱。肥胖女性更容易出现生殖问题，包括不孕、胚胎发育缺陷和后代异常。女性肥胖是一种复杂的多因素疾病，超重和肥胖对这些生殖障碍的发展有许多机制在起作用。胰岛素抵抗、高胰岛素血症和高雄激素血症、脂毒性和炎症是重要的机制。然而，关于它们之间的关联的精确机制尚不清楚。幸运的是，已经发现减肥方法可以逆转母体肥胖对生育能力、胎儿和后代的影响。
