Department of Oncology, Yantai Mountain Hospital, Yantai City, Shandong Province, China.
Comput Math Methods Med. 2022 Aug 17;2022:5188202. doi: 10.1155/2022/5188202. eCollection 2022.
To study the changes in the intestinal flora and its relationship with nutritional status for patients with cancer pain.
A prospective research method was adopted. One hundred twenty cancer patients with cancer pain were selected as the research objects, who were treated in our hospital from June 2019 to June 2020, and 120 cancer patients without cancer pain were selected as the control group, who were treated in the same period. The differences of the intestinal flora and nutritional status of patients with different severity between the observation group and the control group were compared to analyze the changes of intestinal flora in patients with cancer pain and its correlation with nutritional status.
Hemoglobin (HB) ( = 17.141, ≤ 0.001), albumin (ALB) ( = 27.654, ≤ 0.001), prealbumin (PAB) ( = 96.192, ≤ 0.001), and total protein (TP) ( = 18.781, ≤ 0.001) in the observation group were significantly lower than those in the control group. There were statistically significant differences in HB ( = 13.569, ≤ 0.001), ALB ( = 22.229, ≤ 0.001), PAB ( = 19.521, ≤ 0.001), and TP ( = 21.451, ≤ 0.001) among patients with cancer pain of different severity. Through these two comparisons, their nutritional indicators showed a significant downward trend with the increase in the severity for cancer pain patients; the levels of Lactobacillus ( = 2.124, = 0.035), Bifidobacterium ( = 4.823, ≤ 0.001), Enterococcus ( = 3.578, ≤ 0.001), and Eubacterium ( = 2.394, = 0.017) in the observation group were significantly lower than those in the control group. There were statistically significant differences in the levels of Lactobacillus ( = 20.643, ≤ 0.001), Bifidobacterium ( = 19.129, ≤ 0.001), Enterococcus ( = 17.408, ≤ 0.001), and Eubacterium ( = 22.343, ≤ 0.001) among patients with cancer pain of different severity. After pairwise comparison, their beneficial intestinal bacteria were significantly lower than those in the control group with the increase in pain in cancer pain patients. Nitric oxide (NO) ( = 8.418, ≤ 0.001), galectin-3 ( = 14.043, ≤ 0.001), occludin (OCLN) ( = 47.308, ≤ 0.001), galectin-1 ( = 15.298, ≤ 0.001), zonula occludens protein 1 (ZO-1) ( = 23.093, ≤ 0.001), and cingulin ( = 340.198, ≤ 0.001) in the observation group were significantly lower than those in the control group. There were statistically significant differences in NO, galectin-3, OCLN, galectin-1, ZO-1, and cingulin for patients with cancer pain of different severity. By comparison, the NO, galectin-3, OCLN, galectin-1, ZO-1, and cingulin of the patients showed a significant downward trend with the aggravation of cancer pain symptoms. Through correlation analysis, the nutritional indicators of patients were positively correlated with intestinal microorganisms and intestinal barrier function.
There was a significant correlation between the changes in intestinal flora and nutritional status for patients with cancer pain, which could be used as an important basis for improving the treatment of cancer pain.
研究癌症疼痛患者肠道菌群的变化及其与营养状况的关系。
采用前瞻性研究方法，选取我院 2019 年 6 月至 2020 年 6 月收治的 120 例癌症疼痛患者作为观察组，并选取同期我院收治的 120 例无癌症疼痛的癌症患者作为对照组。比较观察组与对照组患者不同严重程度之间肠道菌群的差异及营养状况，分析癌症疼痛患者肠道菌群的变化及其与营养状况的相关性。
观察组血红蛋白（HB）（ = 17.141， ≤ 0.001）、白蛋白（ALB）（ = 27.654， ≤ 0.001）、前白蛋白（PAB）（ = 96.192， ≤ 0.001）和总蛋白（TP）（ = 18.781， ≤ 0.001）明显低于对照组，且观察组中不同严重程度的癌症疼痛患者 HB（ = 13.569， ≤ 0.001）、ALB（ = 22.229， ≤ 0.001）、PAB（ = 19.521， ≤ 0.001）和 TP（ = 21.451， ≤ 0.001）差异均有统计学意义，随着癌症疼痛严重程度的增加，其营养指标呈明显下降趋势；观察组中乳酸杆菌（ = 2.124， = 0.035）、双歧杆菌（ = 4.823， ≤ 0.001）、肠球菌（ = 3.578， ≤ 0.001）和真杆菌（ = 2.394， = 0.017）水平明显低于对照组，且观察组中不同严重程度的癌症疼痛患者乳酸杆菌（ = 20.643， ≤ 0.001）、双歧杆菌（ = 19.129， ≤ 0.001）、肠球菌（ = 17.408， ≤ 0.001）和真杆菌（ = 22.343， ≤ 0.001）差异均有统计学意义，随着癌症疼痛患者疼痛的增加，其有益肠道细菌明显低于对照组；观察组中一氧化氮（NO）（ = 8.418， ≤ 0.001）、半乳糖凝集素-3（ = 14.043， ≤ 0.001）、闭合蛋白（OCLN）（ = 47.308， ≤ 0.001）、半乳糖凝集素-1（ = 15.298， ≤ 0.001）、闭锁小带蛋白 1（ZO-1）（ = 23.093， ≤ 0.001）和纽蛋白（ = 340.198， ≤ 0.001）明显低于对照组，且观察组中不同严重程度的癌症疼痛患者 NO、半乳糖凝集素-3、OCLN、半乳糖凝集素-1、ZO-1 和纽蛋白差异均有统计学意义，随着癌症疼痛症状的加重，其 NO、半乳糖凝集素-3、OCLN、半乳糖凝集素-1、ZO-1 和纽蛋白呈明显下降趋势；通过相关性分析，患者的营养指标与肠道微生物和肠道屏障功能呈正相关。
癌症疼痛患者肠道菌群的变化与营养状况密切相关，可作为改善癌症疼痛治疗的重要依据。
