Cai Qian, Xing Cathleen Y, Zhu Jiang, Wang Ying, Lu Fanghong, Peng Jie
Department of Geriatric Medicine, Qilu Hospital of Shandong University, Jinan, China.
Key Laboratory of Cardiovascular Proteomics of Shandong Province, Qilu Hospital of Shandong University, Jinan, China.
Front Cardiovasc Med. 2022 Aug 11;9:901180. doi: 10.3389/fcvm.2022.901180. eCollection 2022.
Abnormal glycolipid metabolism plays a crucial role in hypertension. While an elevated triglyceride-glucose (TyG) index has been recognized as a risk factor for developing hypertension, the associations between the TyG index and different hypertension subtypes, namely, isolated systolic hypertension (ISH), isolated diastolic hypertension (IDH), and systolic-diastolic hypertension (SDH), remain unclear. This study was designed to investigate the associations between the TyG index and hypertension subtypes in a general Chinese population.
In a sample of 16,793 participants from Shandong Province, China, multivariate logistic regression analyses were performed to examine the associations between the TyG index and different hypertension subtypes. Loess smooth curves were fitted to visualize the trends. Stratified analyses were conducted to further assess the potential interactions in the associations between the TyG index and different hypertension subtypes.
A higher TyG index was associated with an increased odds of having IDH (OR = 2.94, 95% CI: 1.66-5.23) and SDH (OR = 1.82, 95% CI: 1.33-2.49), whereas no apparent relationship was observed between TyG index and ISH. With respect to sex, the effect of TyG index on having IDH and SDH was significant in women, but not in men. Participants with lower lipid profiles and glucose levels demonstrated a stronger strength of association between the TyG index and IDH as compared with the TyG index-SDH association. Stratified analysis showed that participants with a higher TyG index were more than 3 times more likely to have IDH and SDH among persons aged 18-42 years. Significant interactions were observed between TyG index and sex, age, and high-density lipoprotein cholesterol (HDL-C) in the SDH group, and a significant interaction was also found between TyG index and body mass index (BMI) in the ISH group.
Triglyceride-glucose index may potentially serve as a novel indicator for IDH and SDH. Our findings could also inform the development and implementation of targeted screening for hypertension.
异常糖脂代谢在高血压中起关键作用。虽然甘油三酯 - 葡萄糖（TyG）指数升高已被认为是高血压发生的危险因素，但TyG指数与不同高血压亚型，即单纯收缩期高血压（ISH）、单纯舒张期高血压（IDH）和收缩期 - 舒张期高血压（SDH）之间的关联仍不清楚。本研究旨在调查中国普通人群中TyG指数与高血压亚型之间的关联。
在来自中国山东省的16793名参与者样本中，进行多因素逻辑回归分析以检验TyG指数与不同高血压亚型之间的关联。拟合局部加权散点平滑（Loess）曲线以可视化趋势。进行分层分析以进一步评估TyG指数与不同高血压亚型之间关联中的潜在相互作用。
较高的TyG指数与IDH（比值比[OR]=2.94，95%置信区间[CI]：1.66 - 5.23）和SDH（OR = 1.82，95% CI：1.33 - 2.49）发生几率增加相关，而未观察到TyG指数与ISH之间有明显关系。就性别而言，TyG指数对IDH和SDH的影响在女性中显著，但在男性中不显著。与TyG指数 - SDH关联相比，血脂和血糖水平较低的参与者中，TyG指数与IDH之间的关联强度更强。分层分析表明，在18 - 42岁人群中，TyG指数较高的参与者患IDH和SDH的可能性是其他人的3倍以上。在SDH组中观察到TyG指数与性别、年龄和高密度脂蛋白胆固醇（HDL - C）之间存在显著相互作用，在ISH组中也发现TyG指数与体重指数（BMI）之间存在显著相互作用。
甘油三酯 - 葡萄糖指数可能潜在地作为IDH和SDH的新指标。我们的研究结果也可为高血压的针对性筛查的开展和实施提供信息。
