中国各地区高血压风险与甘油三酯葡萄糖指数之间的关联：一项区域更新的系统评价和剂量反应荟萃分析
Association between the risk of hypertension and triglyceride glucose index in Chinese regions: a systematic review and dose-response meta-analysis of a regional update.
作者信息
Xu An-Ran, Jin Qiuyu, Shen Zhisheng, Zhang Jiaqi, Fu Qiang
机构信息
The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, China.
Department of Gastroenterology, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China.
出版信息
Front Cardiovasc Med. 2023 Jul 31;10:1242035. doi: 10.3389/fcvm.2023.1242035. eCollection 2023.
BACKGROUND
Triglyceride-glucose (TyG) index has been reported to be associated with various cardiovascular diseases in recent years. However, the conclusive association between the TyG index and hypertension was not established in the last meta-analysis. Furthermore, it remains unclear whether a linear relationship exists between these two variables.
METHODS
We conducted a comprehensive search of the CNKI, VIP, WanFang Data, CBM, PubMed, EMbase, Web of Science, and The Cochrane Library databases up until May 10, 2023, to identify relevant studies conducted in China. We used Stata version 17.0 and Rstudio version 4.2.1 to analyze the data and assess the association between the TyG index and the risk of hypertension, as well as the dose-response relationship between these two variables. We will select either a random-effects model or a fixed-effects model based on the results of the heterogeneity tests and report 95% confidence intervals accordingly.
RESULTS
In the end, our analysis encompassed 22 studies involving a total of 668,486 participants, comprising 12 cross-sectional studies and 10 cohort studies. Meta-analysis results showed: Analysis of data from China revealed that an elevated TyG index was associated with a higher risk of developing hypertension, as indicated by an OR/HR of 1.36 [95%CI (1.28-1.45) = 69.0% < 0.001]. Through meta-regression analysis of multiple covariates, we found that study type, study region, sample size, database source, and study quality score, the above five variables were able to explain 63.0% of the total heterogeneity. The results of the dose-response Meta-analysis showed: The TyG index has a linear relationship with the risk of developing hypertension, as indicated by non-significant coefficients of higher-order terms in the nonlinear model ( > 0.05). The linear trend analysis showed that for every one-unit increase in the TyG index, the risk of developing hypertension increased by 1.5 times [1.532 95%CI (1.294, 1.813) < 0.001]. However, this result is influenced by the number of studies included in the dose-response analysis and requires further corroboration.
CONCLUSION
In the Chinese region, there was an independent association between TyG index and the risk of developing hypertension, with a linear trend. However, the results of the linear trend need to be corrected by the more number of related studies.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425836.
背景
近年来，甘油三酯-葡萄糖（TyG）指数已被报道与多种心血管疾病相关。然而，在上一次的荟萃分析中，TyG指数与高血压之间的确切关联尚未确立。此外，这两个变量之间是否存在线性关系仍不清楚。
方法
我们全面检索了中国知网、维普、万方数据、中国生物医学文献数据库、PubMed、EMbase、Web of Science和Cochrane图书馆数据库，直至2023年5月10日，以确定在中国进行的相关研究。我们使用Stata 17.0版和Rstudio 4.2.1版来分析数据，并评估TyG指数与高血压风险之间的关联，以及这两个变量之间的剂量反应关系。我们将根据异质性检验的结果选择随机效应模型或固定效应模型，并相应报告95%置信区间。
结果
最终，我们的分析纳入了22项研究，共涉及668,486名参与者，其中包括12项横断面研究和10项队列研究。荟萃分析结果显示：来自中国的数据分析表明，TyG指数升高与患高血压的风险较高相关，OR/HR为1.36 [95%CI（1.28 - 1.45）= 69.0% < 0.001]。通过对多个协变量进行荟萃回归分析，我们发现研究类型、研究地区、样本量、数据库来源和研究质量得分这五个变量能够解释总异质性的63.0%。剂量反应荟萃分析结果显示：TyG指数与患高血压的风险存在线性关系，非线性模型中高阶项系数不显著（> 0.05）表明了这一点。线性趋势分析表明，TyG指数每增加一个单位，患高血压的风险增加1.5倍 [1.532 95%CI（1.294, 1.813） < 0.001]。然而，这一结果受到剂量反应分析中纳入研究数量的影响，需要进一步证实。
结论
在中国地区，TyG指数与患高血压的风险之间存在独立关联，且呈线性趋势。然而，线性趋势的结果需要更多相关研究加以校正。
系统评价注册
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023425836。
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