遗传性神经肌肉疾病患者脑梗死的发生率

Frequency of cerebral infarction in patients with inherited neuromuscular diseases.

作者信息

Biller J, Ionasescu V, Zellweger H, Adams H P, Schultz D T

出版信息

Stroke. 1987 Jul-Aug;18(4):805-7. doi: 10.1161/01.str.18.4.805.

DOI:10.1161/01.str.18.4.805

Abstract

We evaluated the frequency of cerebral infarction in 131 patients with Duchenne's muscular dystrophy, myotonic dystrophy, Becker's muscular dystrophy, or Friedreich's ataxia. Electrocardiographic abnormalities were found in 83% of patients with Duchenne's muscular dystrophy, 56% with myotonic dystrophy, 50% with Becker's muscular dystrophy, and 25% with Friedreich's ataxia. Atrial flutter occurred in 2.3% of the patients, and atrial fibrillation in only 0.9%. Evidence of cerebral infarction was found in only 2 patients (1.5%). Both patients had cardiomyopathy and either atrial fibrillation or flutter. Despite frequent cardiac involvement, cerebral infarction is an uncommon occurrence in patients with inherited neuromuscular diseases.

摘要

我们评估了131例患有杜氏肌营养不良症、强直性肌营养不良症、贝克型肌营养不良症或弗里德赖希共济失调症患者的脑梗死发生率。在杜氏肌营养不良症患者中，83%存在心电图异常；强直性肌营养不良症患者中，56%存在异常；贝克型肌营养不良症患者中，50%存在异常；弗里德赖希共济失调症患者中，25%存在异常。2.3%的患者发生心房扑动，仅0.9%的患者发生心房颤动。仅在2例患者（1.5%）中发现脑梗死证据。这两名患者均患有心肌病且伴有心房颤动或心房扑动。尽管心脏受累常见，但脑梗死在遗传性神经肌肉疾病患者中并不常见。