来自内生真菌的两种西多酸衍生物和一种磺酰基代谢产物。
Two sydowic acid derivatives and a sulfonyl metabolite from the endophytic fungus .
作者信息
Chen Ke-Liang, Sun Sen-Feng, Cao Hai-Yan, Yi Cheng, Yang Chen-Yu, Liu Yun-Bao
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
出版信息
J Asian Nat Prod Res. 2022 Dec;24(12):1128-1133. doi: 10.1080/10286020.2022.2114464. Epub 2022 Aug 27.
Two new sydowic acid derivatives, a pair of enantiomers, involving (+)-sydowiccal () and (-)-sydowiccal (), a new sulfonyl metabolite of 2-methoxy-5-methyl-3-(methylsulfonyl)phenol (), as well as three known sydowic acid derivatives, were isolated from , an endophytic fungus of . The structures of these new compounds were elucidated by analyzing their NMR and HRESIMS data, and the absolute configurations of enantiomers were determined on the basis of the CD spectrum. Three new metabolites showed weak anti-inflammation on nitric oxide (NO) production in LPS-induced RAW 264.7 cells.
从一种植物的内生真菌中分离出两种新的西多酸衍生物，一对对映体，即(+)-西多酸()和(-)-西多酸()，一种2-甲氧基-5-甲基-3-(甲基磺酰基)苯酚()的新磺酰基代谢产物，以及三种已知的西多酸衍生物。通过分析它们的核磁共振和高分辨电喷雾电离质谱数据阐明了这些新化合物的结构，并根据圆二色光谱确定了对映体的绝对构型。三种新代谢产物对脂多糖诱导的RAW 264.7细胞中一氧化氮(NO)的产生显示出微弱的抗炎作用。
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