Department of Otolaryngology Head and Neck Surgery, School of Medicine, Kyung Hee University, Kyung Hee University Medical Center, #1 Hoegi-dong, Dongdaemun-gu, Seoul, 02447, South Korea.
Department of Internal Medicine, School of Medicine, Korea University, Ansan, South Korea.
J Cancer Res Clin Oncol. 2023 Jul;149(7):4005-4013. doi: 10.1007/s00432-022-04288-4. Epub 2022 Aug 29.
Few studies have been conducted on the association between oral cavity cancer and metabolic diseases. This study aimed to investigate the relationship between oral cavity cancer and metabolic diseases.
This cohort study used the database of the Korean National Health Insurance Service, which contains medical data of 97% of the Korean population. Oral cavity cancer occurred in a total of 2718 patients. Metabolic syndrome was defined according to IDF criteria. The Cox proportional hazard regression model was used.
The HR for oral cavity cancer in patients with metabolic syndrome was 1.113(95% CI 1.006-1.232), which was significantly higher than that in normal patients, especially in males (p = 0.0386). When the number of metabolic syndrome factors was ≥ 3, the HR of oral cavity cancer was 1.191(95% CI 1.026-1.383), which was significantly higher than that of 0 metabolic syndrome factors, especially in males (p = 0.0218). When the number of metabolic syndrome factors was ≥ 3, the HR for oral cavity cancer was 1.439(95% CI 1.066-1.942), which was significantly higher than that of 0 metabolic syndrome factors, especially in males aged < 50 years (p = 0.0173).
Metabolic syndrome increases the risk of oral cavity cancer only in males. In addition, the incidence of oral cavity cancer increased as the number of factors constituting metabolic syndrome increased, only in young males aged < 50 years. Thus, metabolic syndrome is an important risk factor for oral cavity cancer, particularly in young males.
鲜有研究探讨口腔癌与代谢疾病之间的关系。本研究旨在调查口腔癌与代谢疾病之间的关联。
本队列研究使用了韩国国家健康保险服务数据库，其中包含了 97%的韩国人口的医疗数据。共有 2718 例口腔癌患者。代谢综合征按照 IDF 标准定义。采用 Cox 比例风险回归模型。
代谢综合征患者口腔癌的 HR 为 1.113（95%CI 1.006-1.232），明显高于正常患者，尤其是男性（p=0.0386）。当代谢综合征因素数≥3 时，口腔癌的 HR 为 1.191（95%CI 1.026-1.383），明显高于无代谢综合征因素的患者，尤其是男性（p=0.0218）。当代谢综合征因素数≥3 时，口腔癌的 HR 为 1.439（95%CI 1.066-1.942），明显高于无代谢综合征因素的患者，尤其是年龄<50 岁的男性（p=0.0173）。
代谢综合征仅会增加男性口腔癌的发病风险。此外，随着构成代谢综合征的因素数量的增加，口腔癌的发病率也会增加，仅在年龄<50 岁的年轻男性中如此。因此，代谢综合征是口腔癌的一个重要危险因素，尤其是在年轻男性中。
