通过碱基编辑介导的 ACCase 靶向进化获得抗除草剂水稻突变体。
Base editing-mediated targeted evolution of ACCase for herbicide-resistant rice mutants.
机构信息
Shanghai Center for Plant Stress Biology and Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, Shanghai, 201602, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
J Integr Plant Biol. 2022 Nov;64(11):2029-2032. doi: 10.1111/jipb.13352. Epub 2022 Sep 26.
PMID:36036619
Abstract
Improved cytosine and adenine base editors and an efficient dual editor were applied in targeted evolution of ACETYL COA CARBOXYLASE in rice, resulting in the generation of dozens of herbicide-resistant mutations, at least three of which, W2125L, W2125Q and C2186H, have not been reported previously.
摘要
改良的胞嘧啶和腺嘌呤碱基编辑器以及高效的双编辑器被应用于水稻中 ACETYL COA CARBOXYLASE 的靶向进化，产生了数十种除草剂抗性突变体，其中至少有三个突变体 W2125L、W2125Q 和 C2186H 以前没有报道过。
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