Perez A J, Petro C C, Higgins R M, Huang L-C, Phillips S, Warren J, Dews T, Reinhorn M
Division of General, Acute Care and Trauma Surgery, Department of Surgery, The University of North Carolina at Chapel Hill, 4008 Burnett Womack, Campus Box 7228, Chapel Hill, NC, 27599-7228, USA.
Center for Abdominal Core Health, Cleveland Clinic, Cleveland, OH, USA.
Hernia. 2022 Dec;26(6):1625-1633. doi: 10.1007/s10029-022-02661-3. Epub 2022 Aug 29.
Prescribing and consumption of opioids remain highly variable. Using a national hernia registry, we aimed to identify patient and surgery specific factors associated with low and high opioid tablet consumption after inguinal hernia repair.
This was a retrospective cross-sectional study evaluating patients undergoing elective inguinal hernia repair with 30-day follow-up and patient-reported opioid consumption from March 2019 to March 2021 using the Abdominal Core Health Quality Collaborative. Clinically significant patient demographics, comorbidities, operative details, quality-of-life measurements, and surgeon prescribing data were entered into a multivariable logistic regression model to identify statistically significant predictors of patients who took no opioid tablets or >10 tablets.
A total of 1937 patients were analyzed. Operations included 59% laparoscopic or robotic, 35% open mesh, and 6% open non-mesh repairs. Of these patients, 50% reported taking zero, 42% took 1-10, and 8% took ≥10 opioid tablets at 30-day follow-up. Patients who were older (OR 1.55, 95% CI 1.34-1.79, p-value <0.001), ASA ≤ 2 (OR 1.56, 95% CI 1.2-2.01, p-value <0.001), had no preoperative opioid use at baseline (OR 2.29, 95% CI 1.31-4.03, p-value = 0.004), had local anesthetic with general anesthesia (OR 1.39, 95% CI 1.0.5-1.85, p-value = 0.022), or prescribed <7 opioid tablets (OR 2.27, 95% CI 1.96-2.62, p-value <0.001) were more likely to take no opioid tablets.
Older, healthier, opioid naïve patients with local anesthetic administered during elective inguinal hernia repair are most likely to not require opioids. Surgeon prescribing-arguably the most modifiable factor-independently correlates with both low and high opioid consumption.
阿片类药物的处方和使用情况仍然存在很大差异。我们利用一个全国性疝气登记处,旨在确定腹股沟疝修补术后阿片类片剂低剂量和高剂量使用情况相关的患者及手术特定因素。
这是一项回顾性横断面研究,评估了2019年3月至2021年3月期间接受择期腹股沟疝修补术且有30天随访以及患者报告的阿片类药物使用情况的患者,使用腹部核心健康质量协作组织的数据。具有临床意义的患者人口统计学特征、合并症、手术细节、生活质量测量以及外科医生的处方数据被纳入多变量逻辑回归模型,以确定未服用阿片类片剂或服用超过10片阿片类片剂的患者的统计学显著预测因素。
共分析了1937例患者。手术方式包括59%的腹腔镜或机器人手术、35%的开放网片修补术和6%的开放非网片修补术。在这些患者中,50%报告在30天随访时服用零片阿片类药物,42%服用1 - 10片,8%服用≥10片阿片类药物。年龄较大的患者(比值比1.55,95%置信区间1.34 - 1.79,p值<0.001)、美国麻醉医师协会身体状况分级≤2级的患者(比值比1.56,95%置信区间1.2 - 2.01,p值<0.001)、基线时术前未使用阿片类药物的患者(比值比2.29,95%置信区间1.31 - 4.03,p值 = 0.004)、接受局部麻醉联合全身麻醉的患者(比值比1.39,95%置信区间1.05 - 1.85,p值 = 0.022)或处方阿片类片剂<7片的患者(比值比2.27,95%置信区间1.96 - 2.62,p值<0.001)更有可能未服用阿片类片剂。
年龄较大、健康状况较好、未使用过阿片类药物且在择期腹股沟疝修补术中接受局部麻醉的患者最有可能不需要使用阿片类药物。外科医生的处方——可以说是最可改变的因素——与阿片类药物的低剂量和高剂量使用均独立相关。