State Key Laboratory of Food Nutrition and Safety, College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, China.
College of Food Engineering & Nutrition Science, Shaanxi Normal University, Shaanxi, China.
Crit Rev Food Sci Nutr. 2024;64(4):1177-1210. doi: 10.1080/10408398.2022.2113366. Epub 2022 Aug 29.
Non-starch polysaccharides (NSPs) have been reported to exert therapeutic potential on managing type 2 diabetes mellitus (T2DM). Various mechanisms have been proposed; however, several studies have not considered the correlations between the anti-T2DM activity of NSPs and their molecular structure. Moreover, the current understanding of the role of NSPs in T2DM treatment is mainly based on and data, and more human clinical trials are required to verify the actual efficacy in treating T2DM. The related anti-T2DM mechanisms of NSPs, including regulating insulin action, promoting glucose metabolism and regulating postprandial blood glucose level, anti-inflammatory and regulating gut microbiota (GM), are reviewed. The structure-function relationships are summarized, and the relationships between NSPs structure and anti-T2DM activity from clinical trials are highlighted. The development of anti-T2DM medication or dietary supplements of NSPs could be promoted with an in-depth understanding of the multiple regulatory effects in the treatment/intervention of T2DM.
非淀粉多糖（NSP）被报道具有治疗 2 型糖尿病（T2DM）的潜力。已经提出了各种机制；然而，一些研究并没有考虑 NSP 的抗 T2DM 活性与其分子结构之间的相关性。此外，目前对 NSP 在 T2DM 治疗中的作用的理解主要基于 和 数据，需要更多的人体临床试验来验证治疗 T2DM 的实际疗效。综述了 NSP 的相关抗 T2DM 机制，包括调节胰岛素作用、促进葡萄糖代谢和调节餐后血糖水平、抗炎和调节肠道微生物群（GM）。总结了结构-功能关系，并强调了临床试验中 NSP 结构与抗 T2DM 活性之间的关系。深入了解 NSP 在 T2DM 治疗/干预中的多种调节作用，可以促进抗 T2DM 药物或 NSP 饮食补充剂的开发。
