Liu Dan, Gao He, Tang Wei, Nie Shaoping
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
Ann N Y Acad Sci. 2017 Aug;1401(1):28-36. doi: 10.1111/nyas.13430.
Type 2 diabetes mellitus (T2DM), a metabolic disease becoming ever more common, is the result of disturbed glyco- and lipid metabolism. On the basis of their inhibitory effects against several key enzymes linked to T2DM, synthetic antidiabetic agents have been developed and used for diabetic therapy, some with adverse side effects. Fortunately, many plant non-starch polysaccharides (NSPs) have been shown to possess inhibitory effects on the same T2DM-related enzymes. Through a simple literature search we found that α-amylase, α-glucosidase, lipase, and dipeptidyl-peptidase IV are the enzymes most often reported in the context of T2DM. In this short review we discuss published evidence for inhibition of these enzymes and the implications for treating T2DM.
2型糖尿病（T2DM）是一种日益常见的代谢性疾病，是糖代谢和脂代谢紊乱的结果。基于对与T2DM相关的几种关键酶的抑制作用，已开发出合成抗糖尿病药物并用于糖尿病治疗，其中一些药物有不良副作用。幸运的是，许多植物非淀粉多糖（NSPs）已被证明对同样与T2DM相关的酶具有抑制作用。通过简单的文献检索，我们发现α-淀粉酶、α-葡萄糖苷酶、脂肪酶和二肽基肽酶IV是在T2DM背景下最常被报道的酶。在这篇简短的综述中，我们讨论了已发表的关于这些酶抑制作用的证据及其对T2DM治疗的意义。
