College of Mechanical and Electrical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
ACS Biomater Sci Eng. 2022 Sep 12;8(9):3659-3675. doi: 10.1021/acsbiomaterials.2c00348. Epub 2022 Aug 29.
Cardiac patches are biomaterials that can be used for transplantation and repair of damaged myocardium by combining seed cells with the ability to form cardiomyocytes and suitable scaffold materials. On the one hand, they provide temporary support to the infarcted area, and on the other hand, they repair the damaged myocardium by delivering cells or bioactive factors to integrate with the host, which have gradually become a hot research topic in recent years. This paper summarizes the structural properties of natural myocardium and reviews the recent research progress of cardiac patches, including the seed cells and scaffold materials used in patch preparation, as well as the main methods of scaffold preparation and the structure properties of various scaffolds. In addition, a comprehensive analysis of the problems faced in the clinical implementation of cardiac patches is presented. Finally, we look forward to the development of cardiac patches and point out that precisely tunable anisotropic tissue engineering scaffolds close to natural myocardial tissue will become an important direction for future research.
心脏补片是一种生物材料，可通过将具有形成心肌细胞能力的种子细胞与合适的支架材料结合，用于受损心肌的移植和修复。一方面，它们为梗死区域提供临时支撑；另一方面，通过向宿主输送细胞或生物活性因子来修复受损的心肌，近年来逐渐成为研究热点。本文总结了天然心肌的结构特性，并综述了心脏补片的最新研究进展，包括补片制备中使用的种子细胞和支架材料，以及支架制备的主要方法和各种支架的结构特性。此外，还对心脏补片在临床实施中面临的问题进行了全面分析。最后，我们对心脏补片的发展进行了展望，并指出精确可调各向异性的接近天然心肌组织的组织工程支架将成为未来研究的一个重要方向。
