Bakare Abiola, Mohanadas Hemanth Ponnambalath, Tucker Nick, Ahmed Waqar, Manikandan A, Faudzi Ahmad Athif Mohd, Mohamaddan Shahrol, Jaganathan Saravana Kumar
School of Engineering, College of Health and Science, Brayford Pool, Lincoln LN6 7TS, United Kingdom.
Abbott Diabetes Care, Alameda, California 94502, USA.
APL Bioeng. 2024 Oct 17;8(4):041503. doi: 10.1063/5.0231856. eCollection 2024 Dec.
In cardiovascular therapeutics, procedures such as heart transplants and coronary artery bypass graft are pivotal. However, an acute shortage of organ donors increases waiting times of patients, which is reflected in negative effects on the outcome for the patient. Post-procedural complications such as thrombotic events and atherosclerotic developments may also have grave clinical implications. To address these challenges, tissue engineering is emerging as a solution, using textile technologies to synthesize biomimetic scaffolds resembling natural tissues. This comprehensive analysis explains methodologies including electrospinning, electrostatic flocking, and advanced textile techniques developed from weaving, knitting, and braiding. These techniques are evaluated in the context of fabricating cardiac patches, vascular graft constructs, stent designs, and state-of-the-art wearable sensors. We also closely examine the interaction of distinct process parameters with the biomechanical and morphological attributes of the resultant scaffolds. The research concludes by combining current findings and recommendations for subsequent investigation.
在心血管治疗领域,心脏移植和冠状动脉搭桥等手术至关重要。然而,器官捐献者的严重短缺增加了患者的等待时间,这对患者的治疗结果产生了负面影响。术后并发症如血栓形成事件和动脉粥样硬化发展也可能具有严重的临床意义。为应对这些挑战,组织工程作为一种解决方案正在兴起,它利用纺织技术合成类似于天然组织的仿生支架。这一全面分析解释了包括静电纺丝、静电植绒以及从织造、针织和编织发展而来的先进纺织技术等方法。这些技术在制造心脏贴片、血管移植物构建体、支架设计以及最先进的可穿戴传感器的背景下进行了评估。我们还仔细研究了不同工艺参数与所得支架的生物力学和形态学属性之间的相互作用。研究最后结合当前研究结果并提出后续研究建议。