[硫胺素及其衍生物对白化小鼠血液和脑组织乙酰胆碱酯酶活性的影响]
[Effect of thiamine and its derivatives on acetylcholinesterase activity of the blood and brain of albino mice].
作者信息
Petrov S A, Rozanov A Ia, Tishchenko D V
出版信息
Ukr Biokhim Zh (1978). 1987 May-Jun;59(3):76-9.
PMID:3603737
Abstract
Thiamine, thiaminepyrophosphate and 4-methyl-5-beta-oxyethylthiazole are studied for their effect on the acetylcholinesterase activity in the brain, blood plasma and cells. The activity of acetylcholinesterase in blood cells is shown to be inhibited most of all by thiamine and thiazole. Acetylcholinesterase of the brain has been efficiently inhibited only by thiamine pyrophosphate.
摘要
研究了硫胺素、硫胺素焦磷酸酯和4-甲基-5-β-氧乙基噻唑对脑、血浆和细胞中乙酰胆碱酯酶活性的影响。结果表明，硫胺素和噻唑对血细胞中乙酰胆碱酯酶的活性抑制作用最强。仅硫胺素焦磷酸酯能有效抑制脑内的乙酰胆碱酯酶。
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