Centre for Biomedical Engineering, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India.
Meerut Institute of Engineering and Technology, Meerut 250005, Uttar Pradesh, India.
Colloids Surf B Biointerfaces. 2022 Oct;218:112785. doi: 10.1016/j.colsurfb.2022.112785. Epub 2022 Aug 24.
Lipid-based vesicular nanoparticles, for instance liposomes, conjugated with polyethylene glycol (PEG) have proven to be the closest to an ideal drug delivery vehicle, making way for several PEG-liposomes based nanomedicines in market. However, the synthetic nature of the nanomaterial poses a threat to stimulate immune system. Alternatively, nanovesicles derived from mammalian cells, such as RBCs, have gained interests as they may not elicit much immune response due to the presence of host specific self-recognition markers on their surface. While several reports demonstrating the superior efficacy of these naturally derived vesicles have come out in the last few years, a comparison with clinically established liposomes is still missing. Thus, we conducted an in-vitro and in-vivo comparative studies between PEG-Liposomes and nanovesicles (NVEs) derived from red blood cell (RBC) membrane with an aim to establish a biocompatible nanocarrier for efficient delivery of chemotherapeutic drugs and photothermal agents.
例如脂质体在内的基于脂质的囊泡与聚乙二醇（PEG）结合已被证明是最接近理想的药物输送载体，为市场上的几种基于 PEG-脂质体的纳米药物铺平了道路。然而，纳米材料的合成性质对免疫系统构成威胁。另一方面，来源于哺乳动物细胞的纳米囊泡，如 RBC，由于其表面存在宿主特异性的自身识别标记物，可能不会引起太多的免疫反应，因此引起了人们的兴趣。尽管在过去几年中已经有几篇报道证明了这些天然来源的囊泡的优越疗效，但与临床应用的脂质体相比，这些研究仍然缺乏。因此，我们进行了 PEG-脂质体和源自红细胞（RBC）膜的纳米囊泡（NVEs）的体外和体内比较研究，旨在建立一种生物相容性的纳米载体，用于有效递送化疗药物和光热试剂。
