Gong Yuxuan, Liu Huaying, Ke Shen, Zhuo Li, Wang Haibin
College of Life Sciences and Bioengineering, School of Physical Science and Engineering, Beijing Jiaotong University, Beijing, China.
Department of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Front Cardiovasc Med. 2023 Jan 4;9:1037741. doi: 10.3389/fcvm.2022.1037741. eCollection 2022.
Cardiovascular disease remains one of the leading causes of death in China, with increasingly serious negative effects on people and society. Despite significant advances in preventing and treating cardiovascular diseases, such as atrial fibrillation/flutter and heart failure over the last few years, much more remains to be done. Therefore, developing innovative methods for identifying and managing cardiovascular disorders is critical. Nanomaterials provide multiple benefits in biomedicine, primarily better catalytic activity, drug loading, targeting, and imaging. Biomimetic materials and nanoparticles are specially combined to synthesize biomimetic nanoparticles that successfully reduce the nanoparticles' toxicity and immunogenicity while enhancing histocompatibility. Additionally, the biological targeting capability of nanoparticles facilitates the diagnosis and therapy of cardiovascular disease. Nowadays, nanomedicine still faces numerous challenges, which necessitates creating nanoparticles that are highly selective, toxic-free, and better clinically applicable. This study reviews the scientific accomplishments in this field over the past few years covering the classification, applications, and prospects of noble metal biomimetic nanozymes and biomimetic nanocarriers.
心血管疾病仍然是中国主要的死因之一,对个人和社会产生的负面影响日益严重。尽管在过去几年中,在预防和治疗心血管疾病(如心房颤动/扑动和心力衰竭)方面取得了重大进展,但仍有许多工作要做。因此,开发识别和管理心血管疾病的创新方法至关重要。纳米材料在生物医学中具有多种优势,主要体现在更好的催化活性、药物负载、靶向性和成像方面。仿生材料和纳米颗粒经过特殊组合,合成出仿生纳米颗粒,成功降低了纳米颗粒的毒性和免疫原性,同时增强了组织相容性。此外,纳米颗粒的生物靶向能力有助于心血管疾病的诊断和治疗。如今,纳米医学仍然面临众多挑战,这就需要制造出具有高选择性、无毒性且更适合临床应用的纳米颗粒。本研究回顾了过去几年该领域的科学成就,涵盖了贵金属仿生纳米酶和仿生纳米载体的分类、应用及前景。