Engineered Zn-based nano-pesticides as an opportunity for treatment of phytopathogens in agriculture.

People's desire for food has never slowed, despite the deterioration of the global agricultural environment and the threat to food security. People rely on agrochemicals to ensure normal crop growth and to relieve the existing demand pressure. Phytopathogens have acquired resistance to traditional pesticides as a result of pesticdes' abuse. Compared with traditional formulations, nano-pesticides have superior antimicrobial performance and are environmentally friendly. Zn-based nanoparticles (NPs) have shown their potential as strong antipathogen activity. However, their full potential has not been demonstrated yet. Here, we analyzed the prerequisites for the use of Zn-based NPs as nano-pesticides in agriculture including both intrinsic properties of the materials and environmental conditions. We also summarized the mechanisms of Zn-based NPs against phytopathogens including direct and indirect strategies to alleviate plant disease stress. Finally, the current challenges and future directions are highlighted to advance our understanding of this field and guide future studies.