School of Population and Public Health, The University of British Columbia, Vancouver, British Columbia, Canada.
British Columbia Women's Hospital and Health Centre, Women's Health Research Institute, Vancouver, British Columbia, Canada.
BMJ Open. 2022 Aug 29;12(8):e062567. doi: 10.1136/bmjopen-2022-062567.
Gathering population-based data on prevalence of SARS-CoV-2 infection is vital to the public health response and planning. Current seroprevalence data in BC are limited with respect to considerations of how socioeconomic and demographic factors, such as age, sex, gender, income, identifying as a visibility minority and occupation, are related to SARS-CoV-2 antibody detection due to infection-acquired immunity. We aimed to estimate the SARS-CoV-2 seropositivity in a cohort of British Columbians, using at-home self-collected dried blood spot (DBS) samples.
This cross-sectional study included online surveys that collected sociodemographic and COVID-19 vaccine receipt information, and an at-home DBS collection kit.
British Columbia (BC), Canada.
Eligible participants were aged 25-69 years and residents of BC.
SARS-CoV-2 anti-spike IgG antibody detection in unvaccinated individuals. Adjusted incidence rate ratios (aIRR) explored factors associated with seropositivity.
SARS-CoV-2 serology was performed on a total of 4048 unvaccinated participants 25-69 years of age who submitted DBS samples taken from November 2020 to June 2021. A total of 118 seropositive cases were identified, for an estimated overall seropositivity of 2.92% (95% CI 2.42% to 3.48%). Participants identifying as a visible minority had a higher seropositivity, 5.1% vs 2.6% (p=0.003), compared with non-visible minority participants. After adjustment by age and sex, identifying as a visible minority (aIRR=1.85, 95% CI 1.20 to 2.84) remained the only significant factor associated with SARS-CoV-2 antibody detection in this cohort of unvaccinated individuals.
SARS-CoV-2 seropositivity in the BC population due to infection-acquired immunity was low. Seropositivity indicated that among those unvaccinated, visible minority communities have been most impacted. Continued monitoring of SARS-CoV-2 serology due to both infection-acquired and vaccine-acquired immunity will be vital in public health planning and pandemic response.
收集 SARS-CoV-2 感染的基于人群的数据对于公共卫生应对和规划至关重要。由于感染获得的免疫，卑诗省目前的血清流行率数据在考虑社会经济和人口因素（如年龄、性别、性别认同、收入、作为少数族裔的身份和职业）与 SARS-CoV-2 抗体检测的关系方面存在局限性。我们旨在使用不列颠哥伦比亚省的一组在家中采集的干血斑 (DBS) 样本估计 SARS-CoV-2 的血清阳性率。
这项横断面研究包括在线调查，收集社会人口统计学和 COVID-19 疫苗接种信息，以及在家中采集 DBS 样本的试剂盒。
加拿大不列颠哥伦比亚省（BC）。
符合条件的参与者年龄在 25-69 岁之间，是不列颠哥伦比亚省的居民。
未接种疫苗个体中 SARS-CoV-2 抗刺突 IgG 抗体的检测。调整后的发病率比 (aIRR) 探讨了与血清阳性相关的因素。
2020 年 11 月至 2021 年 6 月期间，对总共 4048 名年龄在 25-69 岁之间、提交了 DBS 样本的未接种疫苗参与者进行了 SARS-CoV-2 血清学检测。共发现 118 例血清阳性病例，估计总体血清阳性率为 2.92%（95%CI 2.42%至 3.48%）。与非少数族裔参与者相比，自我认同为少数族裔的参与者的血清阳性率更高，为 5.1%对 2.6%（p=0.003）。在按年龄和性别调整后，自我认同为少数族裔（aIRR=1.85，95%CI 1.20 至 2.84）仍然是该未接种疫苗人群中与 SARS-CoV-2 抗体检测相关的唯一显著因素。
由于感染获得的免疫，卑诗省人群中的 SARS-CoV-2 血清阳性率较低。血清阳性表明，在未接种疫苗的人群中，少数族裔社区受到的影响最大。由于感染获得和疫苗获得的免疫，继续监测 SARS-CoV-2 血清学对于公共卫生规划和大流行应对至关重要。
