Division of Cardiovascular and Thoracic Surgery, University of Virginia, Charlottesville, Va.
Department of Emergency Medicine, University of Virginia, Charlottesville, Va.
J Thorac Cardiovasc Surg. 2023 May;165(5):1861-1872.e5. doi: 10.1016/j.jtcvs.2022.07.015. Epub 2022 Jul 31.
Failure to rescue (FTR) is an emerging measure in cardiac surgery, defined as mortality after a postoperative complication. We hypothesized that establishing a medical emergency team (MET) reduced rates of FTR in adults undergoing cardiac surgery.
All patients (N = 11,218) undergoing a The Society of Thoracic Surgeons index operation at our center (1994-2018) were stratified by pre-MET or MET era based on the 2009 institutional implementation of a MET to respond to clinical decompensation in non-intensive-care patients. Patients missing The Society of Thoracic Surgeons predicted risk of mortality were excluded from all cohorts. Risk adjusted multivariable regression analyzed the association of postoperative complications, operative mortality, and FTR by era. Nearest neighbor propensity score matching utilizing patients' The Society of Thoracic Surgeons predicted risk of mortality was performed to create balanced control and exposure groups for secondary subgroup analysis.
In the risk-adjusted multivariable analysis, surgery during the MET era was associated with decreased mortality (odds ratio [OR], 0.51; 95% CI, 0.45-0.77; P < .001), postoperative renal failure (OR, 0.57; 95% CI, 0.46-0.70; P < .001), reoperation (OR, 0.75; 95% CI, 0.59-0.95; P = .017), and deep sternal wound infection (OR, 0.16; 95% CI, 0.04-0.45; P = .002). Surgery performed during the MET era was associated with a decreased rate of FTR in the risk-adjusted analysis (OR, 0.46; 95% CI, 0.34-0.70; P < .001).
The development of an institutional MET program was associated with a decrease in major complications and FTR. These findings support the development of MET programs to improve FTR after cardiac surgery.
术后并发症相关死亡率(Failure to Rescue,FTR)是心脏外科领域的一个新兴指标,定义为术后发生并发症后的死亡率。我们假设建立医疗应急团队(Medical Emergency Team,MET)可降低心脏外科术后 FTR 发生率。
根据 2009 年机构实施 MET 以应对非重症监护患者临床失代偿的时间,将在我们中心接受胸外科医师学会(The Society of Thoracic Surgeons,STS)指数手术的所有患者(N=11218)分为 MET 前时代和 MET 时代。所有队列均排除 STS 预测死亡率缺失的患者。采用多变量回归分析术后并发症、手术死亡率和 FTR 的时代相关性。采用 STS 预测死亡率的最近邻居倾向评分匹配进行二次亚组分析,创建平衡的对照组和暴露组。
在风险调整多变量分析中,MET 时代的手术与死亡率降低相关(比值比 [odds ratio,OR],0.51;95%置信区间 [confidence interval,CI],0.45-0.77;P<.001)、术后肾衰竭(OR,0.57;95%CI,0.46-0.70;P<.001)、再次手术(OR,0.75;95%CI,0.59-0.95;P=0.017)和深部胸骨伤口感染(OR,0.16;95%CI,0.04-0.45;P=0.002)。在风险调整分析中,MET 时代的手术与 FTR 发生率降低相关(OR,0.46;95%CI,0.34-0.70;P<.001)。
机构 MET 项目的发展与主要并发症和 FTR 降低相关。这些发现支持制定 MET 项目以改善心脏手术后的 FTR。