Adeleye Amanda, Cruz Katrina, Cedars Marcelle I, Pasch Lauri, Huddleston Heather
Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, The University of Chicago 5841 South Maryland Avenue, MC 2050, Chicago, IL, 60637, USA.
Center for Reproductive Health, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco 499 Illinois St., San Francisco, CA, 94158, USA.
NPJ Digit Med. 2022 Aug 29;5(1):128. doi: 10.1038/s41746-022-00673-y.
Fertility treatments like in vitro fertilization (IVF) or oocyte cryopreservation (OC) require the daily use of injectable gonadotropins and has been associated with treatment burden and attrition from fertility treatment. We conducted a randomized clinical trial to determine (1) whether educational videos about fertility medications improved infertility self-efficacy scale (ISES), fertility quality of life treatment (FertiQoL-T), and Perceived stress scale (PSS) scores and (2) if such videos improved confidence and reduced medication errors during a first ovarian stimulation cycle. Participants were given access to an online portal with randomized access to either placebo control videos focused on an orientation to IVF or experimental videos that reviewed the preparation and administration of medications used during ovarian stimulation in addition to the placebo videos. Participants completed pre and post-treatment questionnaires. 368 patients enrolled and 257 participants completed the study. There were no differences in ISES, FertiQoL-T or PSS scores between the two groups in an intention-to-treat (p = 0.18, 0.72, and 0.92, respectively) or per-protocol analysis (p = 0.11, 0.38, and 0.37, respectively). In the per protocol analysis, participants who watched experimental videos were four-fold more likely to report confidence administering medications OR 4.70 (95% CI: 2.10, 11.1; p < 0.01) and were 63% less likely to make medication errors OR 0.37 (95% CI: 0.14, 0.90; p = 0.03). Participants had similar likelihoods of rating videos as helpful and recommending videos to others (p = 0.06 and 0.3, respectively). Educational videos about fertility medications may not influence psychological well-being but might improve confidence in medication administration and reduce medication errors. Trial registration number: NCT02979990.
体外受精（IVF）或卵母细胞冷冻保存（OC）等生育治疗需要每天使用注射用促性腺激素，并且与治疗负担以及生育治疗的中断有关。我们进行了一项随机临床试验，以确定：（1）关于生育药物的教育视频是否能提高不孕自我效能量表（ISES）、生育生活质量治疗（FertiQoL-T）和感知压力量表（PSS）得分；（2）此类视频是否能在第一个卵巢刺激周期中提高信心并减少用药错误。参与者可以访问一个在线门户，随机访问侧重于IVF介绍的安慰剂对照视频或除安慰剂视频外还回顾卵巢刺激期间所用药物的制备和给药方法的实验视频。参与者完成了治疗前和治疗后的问卷调查。368名患者入组，257名参与者完成了研究。在意向性分析（分别为p = 0.18、0.72和0.92）或符合方案分析（分别为p = 0.11、0.38和0.37）中，两组之间的ISES、FertiQoL-T或PSS得分均无差异。在符合方案分析中，观看实验视频的参与者报告给药有信心的可能性高出四倍，比值比为4.70（95%置信区间：2.10，11.1；p < 0.01），出现用药错误的可能性低63%，比值比为0.37（95%置信区间：0.14，0.90；p = 0.03）。参与者将视频评为有帮助以及向他人推荐视频的可能性相似（分别为p = 0.06和0.3）。关于生育药物的教育视频可能不会影响心理健康，但可能会提高给药信心并减少用药错误。试验注册号：NCT02979990。
