University of Virginia Department of Ophthalmology, 1300 Jefferson Park Ave., Charlottesville, VA, 22903, USA.
University of Virginia School of Medicine, 200 Jeanette Lancaster Way, Charlottesville, VA, 22903, USA.
Eye (Lond). 2023 Jun;37(8):1678-1682. doi: 10.1038/s41433-022-02214-z. Epub 2022 Aug 29.
BACKGROUND/OBJECTIVE: Asteroid hyalosis (AH) is an uncommon clinical entity of unknown aetiology that is associated with older age. Previous epidemiologic studies have reported various systemic and demographic risk factors for AH but remain limited due to regional constraints of their study populations. Additionally, Hispanic and Non-Hispanic black populations remain under sampled. The aim of this study is to examine the prevalence of asteroid hyalosis in the United States and identify associated factors at a national level.
SUBJECTS/METHODS: This is a population-based, cross-sectional study of 5578 subjects aged 40 and older from the 2005 to 2008 National Health and Nutrition Examination Survey (NHANES). The primary outcome measured was asteroid hyalosis on retinal imaging in any eye. Evaluated risk factors included patient demographics, medical history, body measures, serum markers, and fundus photography findings.
Prevalence of asteroid hyalosis was 0.86% overall, 0.86% in Caucasians, 0.79% in African-Americans, and 0.88% in Hispanics. Asteroid hyalosis was associated with older age (p < 0.0001, 95% confidence interval [CI], 0.06-0.12; odds ratio [OR], 1.09) but not ethnicity or sex. After adjusting for age, greater bodyweight (p = 0.049; 95% CI, 0.001-0.04; OR, 1.02), and history of myocardial infarction (p = 0.022; 95% CI, 0.07-1.55; OR, 2.36) were also found to be significant risk factors.
Asteroid hyalosis is a rare entity in the US associated with older age, greater body weight, and prior history of MI. A potential relationship between AH and cardiovascular disease remains plausible.
背景/目的：星状玻璃体病变（AH）是一种罕见的、病因不明的临床实体，与年龄较大有关。先前的流行病学研究报告了各种与 AH 相关的系统性和人口统计学危险因素，但由于研究人群的地域限制，这些研究仍然有限。此外，西班牙裔和非西班牙裔黑人群体的样本仍然不足。本研究的目的是在美国检查星状玻璃体病变的患病率，并在全国范围内确定相关因素。
受试者/方法：这是一项基于人群的横断面研究，共纳入了 5578 名年龄在 40 岁及以上的 2005 年至 2008 年全国健康和营养调查（NHANES）参与者。主要结局指标是任何一只眼的视网膜成像上的星状玻璃体病变。评估的危险因素包括患者人口统计学、病史、身体测量、血清标志物和眼底摄影结果。
总体患病率为 0.86%，白种人患病率为 0.86%，非裔美国人患病率为 0.79%，西班牙裔患病率为 0.88%。星状玻璃体病变与年龄较大有关（p<0.0001，95%置信区间 [CI]，0.06-0.12；优势比 [OR]，1.09），但与种族或性别无关。在校正年龄后，更大的体重（p=0.049；95%CI，0.001-0.04；OR，1.02）和心肌梗死史（p=0.022；95%CI，0.07-1.55；OR，2.36）也被发现是显著的危险因素。
星状玻璃体病变在美国是一种罕见的疾病，与年龄较大、体重较大和既往心肌梗死史有关。AH 与心血管疾病之间的潜在关系仍然合理。
