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多孔介质中不同形状纳米颗粒对乳腺癌热疗的热分析:一个分数阶模型

Thermal analysis of different shape nanoparticles on hyperthermia therapy on breast cancer in a porous medium: A fractional model.

作者信息

Rahman Ata Ur, Kumam Poom, Watthayu Wiboonsak, Sitthithakerngkiet Kanokwan, Galal Ahmed M

机构信息

Fixed Point Research Laboratory, Fixed Point Theory and Applications Research Group, Center of Excellence in Theoretical and Computational Science (TaCS-CoE), Faculty of Science, King Mongkut's University of Technology Thonburi (KMUTT), 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok, 10140, Thailand.

Center of Excellence in Theoretical and Computational Science (TaCS-CoE), Faculty of Science, King Mongkut's University of Technology Thonburi (KMUTT), 126 Pracha Uthit Rd., Bang Mod, Thung Khru, Bangkok, 10140, Thailand.

出版信息

Heliyon. 2022 Aug 11;8(8):e10170. doi: 10.1016/j.heliyon.2022.e10170. eCollection 2022 Aug.

Abstract

Cancer is clearly a major cause of disease and fatality around the world, yet little is known about how it starts and spreads. In this study, a model in mathematical form of breast cancer guided by a system of (ODE'S) ordinary differential equations is studied in depth to examine the thermal effects of various shape nanoparticles on breast cancer hyperthermia therapy in the existence of a porous media with fractional derivative connection, when utilizing microwave radiative heating. The unsteady state is determined precisely using the Laplace transform approach to crop a more decisive examination of temperature dissemination of blood temperature inside the breast tissues. Durbin's and Zakian's techniques are used to find Laplace inversion. Mild temperature hyperthermia is used in the treatment, which promotes cell death by increasing cell nervousness to radiation therapy and flow of blood in tumor. In the graphical findings, we can witness the distinct behavior of hyperthermia therapy on tumor cells by applying various metabolic heat generation rates across various time intervals to attain the optimal therapeutic temperature point. Particularly, we used graphs to visualize the behavior of different Nanoparticles with different shaped during hypothermia therapy. In comparison to other nanoparticles and shapes, it demonstrates that gold nanoparticles with a platelet shape are the best option for improving heat transmission. Which assess of heat transfer up to 16.412%.

摘要

癌症显然是全球疾病和死亡的主要原因之一,但人们对其如何发生和扩散却知之甚少。在本研究中,深入研究了一个由常微分方程(ODE)系统引导的乳腺癌数学模型,以探讨在存在分数阶导数连接的多孔介质情况下,利用微波辐射加热时各种形状纳米颗粒对乳腺癌热疗的热效应。采用拉普拉斯变换方法精确确定非稳态,以便对乳腺组织内血液温度的温度传播进行更具决定性的研究。使用德宾(Durbin)和扎基安(Zakian)的技术来求拉普拉斯逆变换。治疗中采用温和温度热疗,通过增加细胞对放射治疗的敏感性和肿瘤内的血流来促进细胞死亡。在图形结果中,我们可以通过在不同时间间隔应用各种代谢热生成率来达到最佳治疗温度点,从而见证热疗对肿瘤细胞的不同行为。特别是,我们使用图表来可视化低温治疗期间不同形状的不同纳米颗粒的行为。与其他纳米颗粒和形状相比,结果表明血小板形状的金纳米颗粒是改善热传递的最佳选择。其热传递评估高达16.412%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2cdb/9418218/a8f8fd1bf93a/gr1.jpg

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