神经祖细胞递送双顺磁纳米颗粒后，A/C 磁场可减弱小鼠黑色素瘤。
Attenuation of mouse melanoma by A/C magnetic field after delivery of bi-magnetic nanoparticles by neural progenitor cells.
机构信息
Department of Anatomy and Physiology, 228 Coles Hall, Kansas State University, Manhattan, Kansas 66506, USA.
出版信息
ACS Nano. 2010 Dec 28;4(12):7093-104. doi: 10.1021/nn100870z. Epub 2010 Nov 8.
Abstract
Localized magnetic hyperthermia as a treatment modality for cancer has generated renewed interest, particularly if it can be targeted to the tumor site. We examined whether tumor-tropic neural progenitor cells (NPCs) could be utilized as cell delivery vehicles for achieving preferential accumulation of core/shell iron/iron oxide magnetic nanoparticles (MNPs) within a mouse model of melanoma. We developed aminosiloxane-porphyrin functionalized MNPs, evaluated cell viability and loading efficiency, and transplanted neural progenitor cells loaded with this cargo into mice with melanoma. NPCs were efficiently loaded with core/shell Fe/Fe(3)O(4) MNPs with minimal cytotoxicity; the MNPs accumulated as aggregates in the cytosol. The NPCs loaded with MNPs could travel to subcutaneous melanomas, and after A/C (alternating current) magnetic field (AMF) exposure, the targeted delivery of MNPs by the cells resulted in a measurable regression of the tumors. The tumor attenuation was significant (p < 0.05) a short time (24 h) after the last of three AMF exposures.
摘要
局部磁热疗作为癌症的一种治疗方式重新引起了人们的兴趣，尤其是如果它可以靶向肿瘤部位。我们研究了是否可以利用肿瘤趋向性神经祖细胞（NPC）作为细胞输送载体，以便在黑色素瘤小鼠模型中实现核心/壳铁/氧化铁磁性纳米颗粒（MNP）的优先积累。我们开发了氨基硅氧烷-卟啉功能化的 MNP，评估了细胞活力和负载效率，并将负载这种货物的神经祖细胞移植到患有黑色素瘤的小鼠中。NPC 可以有效地负载具有最小细胞毒性的核/壳 Fe/Fe3O4 MNP；MNP 在细胞质中聚集。负载 MNP 的 NPC 可以迁移到皮下黑色素瘤中，并且在施加 A/C（交流电）磁场（AMF）后，细胞的靶向递送导致肿瘤的可测量消退。在三次 AMF 暴露中的最后一次之后的短时间内（24 小时），肿瘤衰减是显著的（p<0.05）。
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1
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Mol Ther. 2010 Sep;18(9):1650-6. doi: 10.1038/mt.2010.136. Epub 2010 Jul 6.
2
Nanoparticle-induced vascular blockade in human prostate cancer.纳米颗粒诱导的人前列腺癌血管阻断。
Blood. 2010 Oct 14;116(15):2847-56. doi: 10.1182/blood-2010-03-274258. Epub 2010 Jun 29.
3
Preparation and characterization of silica coated iron oxide magnetic nano-particles.二氧化硅包覆氧化铁磁性纳米粒子的制备与表征。
Spectrochim Acta A Mol Biomol Spectrosc. 2010 Sep 1;76(5):484-9. doi: 10.1016/j.saa.2010.04.004. Epub 2010 Apr 24.
4
Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs.联合使用穿瘤肽可提高癌症药物的疗效。
Science. 2010 May 21;328(5981):1031-5. doi: 10.1126/science.1183057. Epub 2010 Apr 8.
5
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6
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Biomaterials. 2010 May;31(13):3694-706. doi: 10.1016/j.biomaterials.2010.01.057. Epub 2010 Feb 7.
7
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Cancer Res. 2010 Jan 15;70(2):471-80. doi: 10.1158/0008-5472.CAN-09-2863. Epub 2010 Jan 12.
8
Tissue-penetrating delivery of compounds and nanoparticles into tumors.化合物和纳米颗粒向肿瘤的组织穿透递送。
Cancer Cell. 2009 Dec 8;16(6):510-20. doi: 10.1016/j.ccr.2009.10.013.
9
Magnetic resonance imaging of mesenchymal stem cells homing to pulmonary metastases using biocompatible magnetic nanoparticles.使用生物相容性磁性纳米颗粒对归巢至肺转移灶的间充质干细胞进行磁共振成像。
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10
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Future Oncol. 2009 Oct;5(8):1237-44. doi: 10.2217/fon.09.99.
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