狼疮肾炎患者焦虑和抑郁的患病率及其危险因素：一项病例对照研究。

Anxiety and depression prevalence and their risk factors in lupus nephritis patients: A case-control study.

机构信息

Department of Nephrology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.

Department of General Therapy, The First Specialized Hospital of Harbin, Harbin, China.

出版信息

Immun Inflamm Dis. 2022 Sep;10(9):e689. doi: 10.1002/iid3.689.

DOI:10.1002/iid3.689

PMID:36039650

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9394231/

Abstract

INTRODUCTION

Anxiety and depression exhibit a high prevalence in systemic lupus erythematosus (SLE) patients, while this issue is seldom explored in lupus nephritis (LN). Hence, the current study aimed to investigate the prevalence of anxiety and depression, and the risk factors for these mental disorders in LN patients.

METHODS

Fifty LN patients, 50 non-LN SLE patients, and 50 health control (HCs) were enrolled. The Hospital Anxiety and Depression Scale (HADS) for anxiety (HADS-A) score and HADS for depression (HADS-D) score were evaluated.

RESULTS

HADS-A score was highest in LN patients (median 7.0, interquartile range [IQR]: 6.0-10.0), followed by non-LN SLE patients (median 6.0, IQR: 5.0-8.0), and lowest in HCs (median 5.0, IQR: 3.0-7.0) (p < .001). Besides, the anxiety rate was most frequent in LN patients (38.0%), followed by non-LN SLE patients (28.0%), least common in HCs (12.0%) (p = .011). HADS-D score was highest in LN patients (median 7.5, IQR: 6.0-11.0), followed by non-LN SLE patients (median 6.0, IQR: 5.0-8.3), and lowest in HCs (median 4.0, IQR: 2.0-6.3) (p < .001). Similarly, the depression rate was most prevalent in LN patients (50.0%), subsequently the non-LN SLE patients (30.0%), and rarest in HCs (10.0%) (p < .001). Furthermore, in LN patients, age (p = .009), LN activity index (p = .020), alopecia (p = .023), 24 h proteinuria (p = .044), and C-reactive protein (p = .049) were independently correlated with higher anxiety risk; meanwhile, age (p = .001) and LN activity index (p = .009) were independently correlated with higher depression risk.

CONCLUSION

Anxiety and depression are highly prevalent, which link to aging, alopecia, inflammation, and severe renal involvement in LN patients.

摘要

简介

焦虑和抑郁在系统性红斑狼疮（SLE）患者中普遍存在，而狼疮肾炎（LN）患者中这一问题很少被探讨。因此，本研究旨在调查 LN 患者中焦虑和抑郁的患病率，以及这些精神障碍的危险因素。

方法

纳入 50 例 LN 患者、50 例非 LN SLE 患者和 50 例健康对照（HC）。采用医院焦虑抑郁量表（HADS）评估焦虑（HADS-A）评分和抑郁（HADS-D）评分。

结果

HADS-A 评分最高的是 LN 患者（中位数 7.0，四分位距 [IQR]：6.0-10.0），其次是非 LN SLE 患者（中位数 6.0，IQR：5.0-8.0），最低的是 HC（中位数 5.0，IQR：3.0-7.0）（p<0.001）。此外，LN 患者的焦虑发生率最高（38.0%），其次是非 LN SLE 患者（28.0%），HC 最低（12.0%）（p=0.011）。HADS-D 评分最高的是 LN 患者（中位数 7.5，IQR：6.0-11.0），其次是非 LN SLE 患者（中位数 6.0，IQR：5.0-8.3），最低的是 HC（中位数 4.0，IQR：2.0-6.3）（p<0.001）。同样，LN 患者的抑郁发生率最高（50.0%），其次是非 LN SLE 患者（30.0%），HC 最低（10.0%）（p<0.001）。此外，在 LN 患者中，年龄（p=0.009）、LN 活动指数（p=0.020）、脱发（p=0.023）、24 小时蛋白尿（p=0.044）和 C 反应蛋白（p=0.049）与较高的焦虑风险独立相关；而年龄（p=0.001）和 LN 活动指数（p=0.009）与较高的抑郁风险独立相关。