Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
J Diabetes. 2022 Aug;14(8):532-540. doi: 10.1111/1753-0407.13301. Epub 2022 Aug 20.
Initial reports show an increase in youth onset type 2 diabetes during the COVID-19 pandemic. We aim to expand on existing evidence by analyzing trends over a longer period.
Our study aims to describe change in the amount, severity, and demographics of youth onset type 2 diabetes diagnoses during the COVID-19 pandemic compared to the five years before.
We performed a retrospective cross-sectional review of youth (age ≤ 21) diagnosed with type 2 diabetes during the COVID-19 pandemic (1 May 2020-30 April 2021) and the five years before (1 May 2015-30 April 2020) at a tertiary care center. Children were identified by International Classification of Diseases codes. Charts were reviewed to confirm diagnosis. Chi-square, t tests, and Fisher's exact tests were used for analyses.
In the prepandemic era annual diagnoses of type 2 diabetes ranged from 41-69 (mean = 54.2), whereas during the pandemic period 159 children were diagnosed, an increase of 293%. The increase resulted in a higher incidence rate ratio during the pandemic than before, 2.77 versus 1.07 (p = .006). New diagnoses increased most, by 490%, in Non-Hispanic Black patients. The average HbA at presentation was higher during the pandemic (9.5% ± 2.6) (79.9 mmol/mol ± 28.2) than before (8.7%±2.1) (72.1 mmol/mol ± 23.1) (p = .003). Of those diagnosed during the pandemic, 59% were tested for COVID-19 and three tested positive.
New diagnoses of type 2 diabetes increased during the pandemic, most notably in Non-Hispanic Black youth. There was not a significant correlation found with clinical or biochemical COVID-19 infection in those tested.
最初的报告显示，在 COVID-19 大流行期间，青少年 2 型糖尿病的发病年龄有所提前。我们旨在通过分析更长时间段内的趋势来扩展现有证据。
我们的研究旨在描述 COVID-19 大流行期间与大流行前五年相比，青少年（年龄≤21 岁）2 型糖尿病诊断数量、严重程度和人口统计学特征的变化。
我们对一家三级保健中心在 COVID-19 大流行期间（2020 年 5 月 1 日至 2021 年 4 月 30 日）和大流行前五年（2015 年 5 月 1 日至 2020 年 4 月 30 日）期间诊断为 2 型糖尿病的青少年（年龄≤21 岁）进行了回顾性横断面研究。通过国际疾病分类代码识别儿童。对图表进行了审查以确认诊断。采用卡方检验、t 检验和 Fisher 精确检验进行分析。
在大流行前时期，每年诊断出的 2 型糖尿病病例数在 41-69 例之间（平均 54.2 例），而在大流行期间则诊断出 159 例，增加了 293%。这导致大流行期间的发病率比率高于大流行前，分别为 2.77 和 1.07（p=0.006）。非西班牙裔黑人患者的新诊断病例增加最多，增加了 490%。大流行期间的平均 HbA1c 水平更高（9.5%±2.6）（79.9mmol/mol±28.2），而大流行前的平均 HbA1c 水平较低（8.7%±2.1）（72.1mmol/mol±23.1）（p=0.003）。在大流行期间被诊断出的患者中，59%接受了 COVID-19 检测，其中 3 例检测结果为阳性。
在大流行期间，新诊断出的 2 型糖尿病病例有所增加，尤其是在非西班牙裔黑人青少年中。在接受检测的患者中，未发现与 COVID-19 感染的临床或生化特征有显著相关性。
