Institute of Epidemiology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Clinic of Neurology, University Clinical Center of Serbia, Dr Subotica 6, 11000 Belgrade, Belgrade, Serbia.
Neurol Sci. 2022 Dec;43(12):6839-6846. doi: 10.1007/s10072-022-06362-8. Epub 2022 Aug 30.
Among different comorbidities occurring in multiple sclerosis (MS), the presence of malignant diseases in these patients is of the particular importance. The aim of this study was to determine the malignant diseases burden in a whole cohort of patients with MS in the Belgrade region, based on the Belgrade population registry data.
This study comprises 2725 MS patients from the MS Registry, which represents a source for all necessary demographic and clinical data. Firstly, the Registry was searched for all persons with MS who had cancer comorbidity, during the period 1996-2019. Diagnosis of cancer was validated by the patients' medical documentation. In order to investigate factors associated with the occurrence of any type of the cancer and/ or breast cancer only, in persons with MS, different logistic regression analyses were performed.
A total of 64 persons with 69 malignant diseases were observed (prevalence 2.53%). The most frequent malignancies in males were skin cancer (50.0%) and in females, breast cancer (23.2%). The cumulative incidence of cancer comorbidity in persons with MS was 324.9 new cases per 100,000 person-years for the total population (137.6/100,000 in males and 403.6 per 100,000 in females). Comparison of cancer incidence rate between MS and general Belgrade population revealed lower risk for malignancy occurrence in the MS population in total (standardized incidence ratio, SIR = 0.58, 95% CI 0.16-1.49).
Our findings demonstrate that MS patients in the Belgrade region have lower risk for the development of malignancy than age- and sex-matched general population.
在多发性硬化症（MS）中发生的各种合并症中，这些患者的恶性疾病尤其重要。本研究的目的是基于贝尔格莱德人口登记数据，确定贝尔格莱德地区所有 MS 患者的恶性疾病负担。
本研究包括来自 MS 登记处的 2725 名 MS 患者，该登记处是所有必要的人口统计学和临床数据的来源。首先，在 1996 年至 2019 年期间，登记处搜索了所有患有 MS 合并癌症的患者。通过患者的医疗记录验证癌症的诊断。为了研究与 MS 患者发生任何类型癌症和/或乳腺癌相关的因素，进行了不同的逻辑回归分析。
共观察到 64 名患者患有 69 种恶性疾病（患病率为 2.53%）。男性中最常见的恶性肿瘤是皮肤癌（50.0%），女性中最常见的是乳腺癌（23.2%）。MS 患者的癌症合并症累积发病率为每 100,000 人年有 324.9 例新发病例，总人群中为 137.6/100,000 例（男性为 137.6/100,000 例，女性为 403.6/100,000 例）。MS 人群与普通贝尔格莱德人群的癌症发病率比较表明，MS 人群的恶性肿瘤发生风险较低（标准化发病率比，SIR=0.58，95%CI 0.16-1.49）。
我们的研究结果表明，与年龄和性别匹配的普通人群相比，贝尔格莱德地区的 MS 患者发生恶性肿瘤的风险较低。
