Benjaminsen Espen, Myhr Kjell-Morten, Grytten Nina, Alstadhaug Karl Bjørnar
Department of Neurology, Nordland Hospital Trust, Bodø, Norway; Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway.
Department of Clinical Medicine, University of Bergen, Bergen, Norway; Neuro-SysMed, Department of Neurology Haukeland University Hospital, Bergen, Norway.
Mult Scler Relat Disord. 2021 Feb;48:102691. doi: 10.1016/j.msard.2020.102691. Epub 2020 Dec 21.
Knowledge of comorbid disorders is important to optimize therapy for multiple sclerosis (MS), but data are limited. The aim of this study was to assess comorbidity in persons with MS living in Nordland County on January 1, 2017.
Data were retrieved from the Norwegian Patient Registry (2008-2017) and validated through review of electronic hospital charts (1970-2017). Comorbidity was defined as any distinct disorder, classified in the International Classification of Diseases (ICD-10), that had existed or occurred after the diagnosis of MS was established.
Data from 637 subjects were reviewed, and 97.5% were registered with at least one comorbid condition. Malignant melanoma was found in 0.5%, and non-melanoma skin cancers in 1.9%. In female subjects, breast cancer was found in 3.3%. Hypothyroidism was confirmed in 3.1%, type-1 diabetes in 0.3%, type-2 diabetes in 3.9%, psychosis in 0.6%, epilepsy in 2.8%, myocardial infarction in 1.7%, subarachnoid hemorrhage in 0.2%, cerebral infarction in 0.6%, pulmonary embolism in 0.9%, inflammatory bowel disease in 1.3%, and rheumatoid arthritis in 0.6%.
Compared to reports from other Norwegian epidemiological studies, a higher proportion of inflammatory bowel disease and epilepsy was found. This is in accordance with findings from other studies. The prevalence of non-melanoma skin cancers was significantly higher than in the general Norwegian population as they were reported by The Cancer Registry of Norway.
了解合并症对于优化多发性硬化症（MS）的治疗很重要，但相关数据有限。本研究的目的是评估2017年1月1日居住在诺尔兰郡的MS患者的合并症情况。
数据取自挪威患者登记处（2008 - 2017年），并通过查阅电子医院病历（1970 - 2017年）进行验证。合并症定义为在MS诊断确立后已经存在或发生的、按照国际疾病分类（ICD - 10）分类的任何一种不同的疾病。
对637名受试者的数据进行了审查，97.5%的受试者登记有至少一种合并症。发现0.5%的受试者患有恶性黑色素瘤，1.9%患有非黑色素瘤皮肤癌。在女性受试者中，3.3%患有乳腺癌。确诊3.1%患有甲状腺功能减退症，0.3%患有1型糖尿病，3.9%患有2型糖尿病，0.6%患有精神病，2.8%患有癫痫，1.7%患有心肌梗死，0.2%患有蛛网膜下腔出血，0.6%患有脑梗死，0.9%患有肺栓塞，1.3%患有炎症性肠病，0.6%患有类风湿性关节炎。
与挪威其他流行病学研究的报告相比，发现炎症性肠病和癫痫的比例更高。这与其他研究的结果一致。非黑色素瘤皮肤癌的患病率明显高于挪威癌症登记处报告的挪威普通人群。
