Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St Lucia, Queensland 4072, Australia.
ACS Appl Mater Interfaces. 2022 Sep 14;14(36):41400-41411. doi: 10.1021/acsami.2c09698. Epub 2022 Aug 30.
Antifouling and antibacterial surfaces that can prevent nonspecific biological adhesion are important to support a myriad of biomedical applications. In this study, we have used an innovative photopolymerization technology to develop sulfur-containing polymer-grafted antifouling and antibacterial surfaces. The relationship between the hydrophilic property and the capability to resist protein and macrophage adsorption of the surface copolymer brushes was investigated. The sulfide monomer incorporated into the surface copolymer brushes can be further ionized to carry positive charges and impart antibacterial activity, leading to surfaces with dual antifouling and antibacterial functions. We believe that the reported sulfur-containing polymer brushes can be considered an emerging and important polymer for antifouling and antibacterial applications.
具有抗生物污损和抗菌功能的表面可以防止非特异性生物黏附，对于支持众多生物医学应用非常重要。在这项研究中，我们使用了一种创新的光聚合技术，开发了含硫聚合物接枝的抗生物污损和抗菌表面。研究了表面共聚刷的亲水性与抵抗蛋白质和巨噬细胞吸附能力之间的关系。引入表面共聚刷的硫化物单体可以进一步离解，携带正电荷，并赋予抗菌活性，从而使表面具有双重抗生物污损和抗菌功能。我们相信，所报道的含硫聚合物刷可以被认为是一种新兴的、用于抗生物污损和抗菌应用的重要聚合物。
