School of Chemistry and Materials Science, University of Science and Technology of China, Jinzhai Road 96, Hefei, Anhui, PR China; Department of thyroid and breast Surgery, The First Affiliated Hospital of USTC, Tian'ehu Road 1, Hefei, Anhui, PR China; State Key Laboratory of Fire Science, University of Science and Technology of China, Huangshan Road 443, Hefei, Anhui, PR China.
State Key Laboratory of Fire Science, University of Science and Technology of China, Huangshan Road 443, Hefei, Anhui, PR China.
Biomater Adv. 2022 Sep;140:213091. doi: 10.1016/j.bioadv.2022.213091. Epub 2022 Aug 27.
The biocompatible nanosystem integrating hemin into black phosphorus nanosheets was ingeniously constructed through the easy modified strategy. Taking advantage of the enhanced permeability and retention (EPR) effect, the designed nanosystem could accumulate into the tumor location, leading to attractive cytotoxicity through the enhanced photodynamic therapy (PDT) ascribing to the catalytic oxygen supply and GSH depletion of hemin. Simultaneously, combining PDT and photothermal therapy (PTT) showed an apparent promotion in anti-tumor effect. Moreover, inflammatory response and immune activation amplified anti-tumor effect, which could compensate limitations of exogenous therapy (i.e., limited tissue depth and intensity-dependent curation effect) and potentiate the efficiency of the endogenous immune-activating behavior. Especially, the designed nanosystem degraded followed by being metabolized in the blood circulation. By and large, this constructed nanosystem provides the new insight into designing biocompatible nanomaterials and paves the ideal way for anti-tumor therapy. STATEMENT OF SIGNIFICANCE: Biocompatible nanomaterials-based synergistic tumor therapy offers the potential application prospect. Taking advantage of degradable black phosphorus, the nanosystem integrating hemin into black phosphorus for the enhanced photodynamic therapy and synergistic photothermal-photodynamic activating inflammation-immune response was developed and the results demonstrate that tumor growth was inhibited followed by activating inflammatory factors and leading to satisfactory immune response.
通过简单的修饰策略，成功构建了将血红素整合到黑磷纳米片中的生物相容性纳米系统。利用增强型通透性和保留效应（EPR），设计的纳米系统可以聚集到肿瘤部位，通过血红素的催化供氧和 GSH 耗竭，产生吸引人的细胞毒性，从而实现增强的光动力治疗（PDT）。同时，PDT 和光热治疗（PTT）的结合显示出明显促进抗肿瘤效果。此外，炎症反应和免疫激活增强了抗肿瘤效果，这可以弥补外源性治疗的局限性（即有限的组织深度和强度依赖性治疗效果），并增强内源性免疫激活行为的效率。特别是，设计的纳米系统在血液循环中降解并被代谢。总的来说，该构建的纳米系统为设计生物相容性纳米材料提供了新的见解，并为抗肿瘤治疗铺平了理想的道路。
