Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, USA.
Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Obesity (Silver Spring). 2022 Oct;30(10):1914-1916. doi: 10.1002/oby.23539. Epub 2022 Aug 30.
Sleep is an ancient and evolutionarily conserved biological process that, when disturbed, increases the risk for a variety of diseases in people, including diabetes, cardiovascular disease, kidney disease, and cancer. Although results from epidemiological studies support the link between insufficient sleep and an increased risk of obesity, the directionality of this link is unknown. Results from short-term controlled clinical studies, conducted almost exclusively in people who are normal weight, demonstrate that sleep restriction increases hunger, appetite, energy intake, and body weight. However, the authors are not aware of any studies that have evaluated the effect of more than 3 weeks of experimental sleep restriction on obesity risk factors, and few studies have been conducted in people with preexisting obesity. This Perspective reviews the link between insufficient sleep and obesity risk and the potential therapeutic effects of sleep extension in people with chronic sleep insufficiency.
睡眠是一种古老而进化上保守的生物过程，当它受到干扰时，会增加人们患上各种疾病的风险，包括糖尿病、心血管疾病、肾脏疾病和癌症。尽管来自流行病学研究的结果支持睡眠不足与肥胖风险增加之间的联系，但这种联系的方向性尚不清楚。几乎完全在体重正常的人群中进行的短期对照临床试验的结果表明，睡眠限制会增加饥饿感、食欲、能量摄入和体重。然而，作者不知道有任何研究评估了超过 3 周的实验性睡眠限制对肥胖风险因素的影响，而且在患有肥胖症的人群中进行的研究很少。本观点回顾了睡眠不足与肥胖风险之间的联系，以及在慢性睡眠不足人群中延长睡眠时间的潜在治疗效果。
