Key Laboratory of Flexible Electronics & Institute of Advanced Materials, Nanjing Tech University, Nanjing, 211800, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Nat Commun. 2022 Aug 30;13(1):5091. doi: 10.1038/s41467-022-32054-0.
X-ray-induced photodynamic therapy utilizes penetrating X-rays to activate reactive oxygen species in deep tissues for cancer treatment, which combines the advantages of photodynamic therapy and radiotherapy. Conventional therapy usually requires heavy-metal-containing inorganic scintillators and organic photosensitizers to generate singlet oxygen. Here, we report a more convenient strategy for X-ray-induced photodynamic therapy based on a class of organic phosphorescence nanoscintillators, that act in a dual capacity as scintillators and photosensitizers. The resulting low dose of 0.4 Gy and negligible adverse effects demonstrate the great potential for the treatment of deep tumours. These findings provide an optional route that leverages the optical properties of purely organic scintillators for deep-tissue photodynamic therapy. Furthermore, these organic nanoscintillators offer an opportunity to expand applications in the fields of biomaterials and nanobiotechnology.
X 射线诱导光动力疗法利用穿透性 X 射线在深层组织中激活活性氧物种以治疗癌症，它结合了光动力疗法和放射疗法的优点。传统疗法通常需要含重金属的无机闪烁体和有机光敏剂来产生单线态氧。在这里，我们报告了一种基于一类有机磷光纳米闪烁体的更方便的 X 射线诱导光动力治疗策略，该策略兼具闪烁体和光敏剂的双重功能。所得到的低剂量 0.4Gy 和可忽略的副作用表明，该策略在治疗深部肿瘤方面具有巨大的潜力。这些发现为利用纯有机闪烁体的光学特性进行深层组织光动力治疗提供了一种可选途径。此外，这些有机纳米闪烁体为生物材料和纳米生物技术领域的应用提供了机会。
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