Centre for Drug Discovery and Development, Col. Dr. Jeppiaar Research Park, Sathyabama Institute of Science and Technology Jeppiaar Nagar, Rajiv Gandhi Road, Chennai, 600 119, India.
Departmentof Microbiology, Centre of Excellence in Life Sciences, Bharathidasan University, Tiruchirappalli, 620 024, Tami Nadu, India.
Sci Rep. 2022 Aug 30;12(1):14757. doi: 10.1038/s41598-022-18379-2.
World-wide antimicrobial resistant is biggest threat in global health. It requires the urgent need of multisectoral action for the scientific community to achieve the sustainable development Goals. Due to their antimicrobial properties, silver nanoparticles are potential activates to pathogens, which explains their potential for multiple applications in various fields. In the present studies, we evaluate the antimicrobial properties of a Sargassum polycystum algal extract, an unrivaled green synthetic method for producing -defined shaped seaweed silver nanoparticles. To confirm their structure and size, some characterization techniques are used, such as Absorption spectrophotometer (UV-VIS), Fourier transforms infrared spectroscopy (FTIR), Scanning electron Microscope (SEM), Transmission electron microscopy (TEM) and X-Ray diffraction (XRD). Evaluate the antibacterial and anti-mycobacterial activity using silver nanoparticles. The toxicity study of this silver nanoparticle has been done with the help of zebrafish larva. The biological nanoparticle having good antimicrobial activity against Staphylococcus aureus, Micrococcus luteus, Pseudomonas fluorescens and Candida albicans and also it shows potent activity against MTB H37Rv, SHRE sensitive MTB Rifampicin resistant MTB around 98%. Seaweed nanoparticles had lower toxicity for the survival of the fish larvae. In comparison, other dosages will arrest the cell cycle and leads to death. The present finding revealed that these seaweeds nanoparticles have potential anti-mycobacterial activity against pathogens at low concentrations. This makes them a potent source of antibacterial and anti-TB agents.
全球范围内的抗生素耐药性是全球健康面临的最大威胁。这就需要科学界采取多部门行动，以实现可持续发展目标。由于银纳米粒子具有抗菌特性，它们是对抗病原体的潜在激活物，这解释了它们在各个领域的多种应用潜力。在目前的研究中，我们评估了马尾藻多糖藻类提取物的抗菌特性，这是一种无与伦比的绿色合成方法，可用于生产具有定义形状的海藻银纳米粒子。为了确认它们的结构和尺寸，使用了一些表征技术，如吸收分光光度计（UV-VIS）、傅里叶变换红外光谱（FTIR）、扫描电子显微镜（SEM）、透射电子显微镜（TEM）和 X 射线衍射（XRD）。使用银纳米粒子评估抗菌和抗分枝杆菌活性。在斑马鱼幼虫的帮助下，进行了这种银纳米粒子的毒性研究。该生物纳米颗粒对金黄色葡萄球菌、微球菌、荧光假单胞菌和白色念珠菌具有良好的抗菌活性，对 H37Rv 型结核分枝杆菌、SHRE 敏感型结核分枝杆菌和 Rifampicin 耐药型结核分枝杆菌也具有很强的活性，约为 98%。海藻纳米粒子对鱼类幼虫的生存毒性较低。相比之下，其他剂量会阻止细胞周期并导致死亡。目前的发现表明，这些海藻纳米粒子在低浓度下对病原体具有潜在的抗分枝杆菌活性。这使它们成为抗菌和抗结核药物的潜在来源。
