评估源于褐藻的纳米银：抗氧化、抗癌、抗菌和保肝作用的深入研究。

Assessment of Silver Nanoparticles Derived from Brown Algae Insight into Antioxidants, Anticancer, Antibacterial and Hepatoprotective Effect.

机构信息

Department of Biology, College of Sciences and Arts Khulais, University of Jeddah, Jeddah 21959, Saudi Arabia.

Microbial Biotechnology Department, Genetic Engineering and Biotechnology Research Institute, University of Sadat City, Sadat City 32897, Egypt.

出版信息

Mar Drugs. 2024 Mar 28;22(4):154. doi: 10.3390/md22040154.

Algae are used as safe materials to fabricate novel nanoparticles to treat some diseases. Marine brown alga are used to fabricate silver nanoparticles (Sv/Ag-NPs). The characterization of Sv/Ag-NPs was determined by TEM, EDX, Zeta potential, XRD, and UV spectroscopy. The Sv/Ag-NPs were investigated as antioxidant, anticancer, and antibacterial activities against Gram-positive bacteria PP400982, PP401704, PP402689, and PP403851. The activity of the Sv/Ag-NPs was evaluated as hepatoprotective in vitro in comparison with silymarin. The UV-visible spectrum of Sv/Ag-NPs appeared at 442 nm; the size of Sv/Ag-NPs is in range between 6.90 to 16.97 nm, and spherical in shape. Different concentrations of Sv/Ag-NPs possessed antioxidant, anticancer activities against (HepG-2), colon carcinoma (HCT-116), cervical carcinoma (HeLa), and prostate carcinoma (PC-3) with IC50 50.46, 45.84, 78.42, and 100.39 µg/mL, respectively. The Sv/Ag-NPs induced the cell viability of Hep G2 cells and hepatocytes treated with carbon tetrachloride. The Sv/Ag-NPs exhibited antibacterial activities against PP401704, PP402689, and PP403851. This study strongly suggests the silver nanoparticles derived from showed potential hepato-protective effect against carbon tetrachloride-induced liver cells, and could be used as anticancer and antibacterial activities.

藻类被用作制造新型纳米颗粒的安全材料，以治疗某些疾病。海洋褐藻被用来制造银纳米颗粒（Sv/Ag-NPs）。Sv/Ag-NPs 的特性通过 TEM、EDX、Zeta 电位、XRD 和 UV 光谱来确定。Sv/Ag-NPs 被研究为具有抗氧化、抗癌和抗革兰氏阳性菌（PP400982、PP401704、PP402689 和 PP403851）的抗菌活性。Sv/Ag-NPs 的活性在体外与水飞蓟素进行比较，被评估为具有肝保护作用。Sv/Ag-NPs 的紫外-可见光谱在 442nm 处出现；Sv/Ag-NPs 的尺寸在 6.90 到 16.97nm 之间，呈球形。不同浓度的 Sv/Ag-NPs 具有抗氧化、抗癌活性，对（HepG-2）、结肠癌细胞（HCT-116）、宫颈癌细胞（HeLa）和前列腺癌细胞（PC-3）的 IC50 分别为 50.46、45.84、78.42 和 100.39μg/mL。Sv/Ag-NPs 诱导用四氯化碳处理的 Hep G2 细胞和肝细胞的细胞活力。Sv/Ag-NPs 对 PP401704、PP402689 和 PP403851 表现出抗菌活性。这项研究强烈表明，来源于的银纳米颗粒对四氯化碳诱导的肝细胞具有潜在的肝保护作用，并可用于抗癌和抗菌活性。