Laboratory of Stem Cell Regulation With Chinese Medicine and Its Application, School of Pharmacy, Hunan University of Chinese Medicine, 300 Xueshi Road, Hanpu Science and Education District, 410208, Changsha, Hunan, People's Republic of China.
Department of Urology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China.
Stem Cell Res Ther. 2022 Aug 30;13(1):432. doi: 10.1186/s13287-022-03111-8.
Cancer stem cells (CSCs) are a subpopulation of cancer cells with stem cell properties that sustain cancers, which may be responsible for cancer metastasis or recurrence. Lipid rafts are cholesterol- and sphingolipid-enriched microdomains in the plasma membrane that mediate various intracellular signaling. The occurrence and progression of cancer are closely related to lipid rafts. Emerging evidence indicates that lipid raft levels are significantly enriched in CSCs compared to cancer cells and that most CSC markers such as CD24, CD44, and CD133 are located in lipid rafts. Furthermore, lipid rafts play an essential role in CSCs, specifically in CSC self-renewal, epithelial-mesenchymal transition, drug resistance, and CSC niche. Therefore, lipid rafts are critical regulatory platforms for CSCs and promising therapeutic targets for cancer therapy.
肿瘤干细胞（CSCs）是一类具有干细胞特性的肿瘤细胞亚群，能够维持肿瘤的生长，可能与肿瘤的转移或复发有关。脂筏是质膜中富含胆固醇和鞘脂的微区，介导多种细胞内信号转导。肿瘤的发生和发展与脂筏密切相关。新出现的证据表明，与肿瘤细胞相比，CSC 中脂筏的水平显著富集，并且大多数 CSC 标志物，如 CD24、CD44 和 CD133，都位于脂筏中。此外，脂筏在 CSCs 中发挥着重要作用，特别是在 CSC 自我更新、上皮-间充质转化、耐药性和 CSC 生态位中。因此，脂筏是 CSCs 的关键调控平台，也是癌症治疗有前途的治疗靶点。
