Department Medical Chemistry, Biochemistry and Clinical Chemistry, Faculty of Medicine Osijek, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Department of Biology, Josip Juraj Strossmayer University of Osijek, 31000 Osijek, Croatia.
Biomolecules. 2024 Mar 18;14(3):362. doi: 10.3390/biom14030362.
Lipid rafts, specialised microdomains within cell membranes, play a central role in orchestrating various aspects of neurodevelopment, ranging from neural differentiation to the formation of functional neuronal networks. This review focuses on the multifaceted involvement of lipid rafts in key neurodevelopmental processes, including neural differentiation, synaptogenesis and myelination. Through the spatial organisation of signalling components, lipid rafts facilitate precise signalling events that determine neural fate during embryonic development and in adulthood. The evolutionary conservation of lipid rafts underscores their fundamental importance for the structural and functional complexity of the nervous system in all species. Furthermore, there is increasing evidence that environmental factors can modulate the composition and function of lipid rafts and influence neurodevelopmental processes. Understanding the intricate interplay between lipid rafts and neurodevelopment not only sheds light on the fundamental mechanisms governing brain development but also has implications for therapeutic strategies aimed at cultivating neuronal networks and addressing neurodevelopmental disorders.
脂质筏，细胞膜内的特化微域，在协调神经发育的各个方面起着核心作用，从神经分化到功能性神经网络的形成。本综述重点关注脂质筏在关键神经发育过程中的多方面作用，包括神经分化、突触形成和髓鞘形成。通过信号成分的空间组织，脂质筏促进了精确的信号事件，这些事件决定了胚胎发育和成年期神经命运。脂质筏的进化保守性突出了它们对所有物种中神经系统结构和功能复杂性的基本重要性。此外，越来越多的证据表明，环境因素可以调节脂质筏的组成和功能，并影响神经发育过程。理解脂质筏和神经发育之间的复杂相互作用不仅揭示了控制大脑发育的基本机制，而且对旨在培养神经元网络和解决神经发育障碍的治疗策略也具有重要意义。
