轻度认知障碍患者认知和身体功能的运动训练：一项符合 PRISMA 原则的系统评价和荟萃分析。

Exercise training for cognitive and physical function in patients with mild cognitive impairment: A PRISMA-compliant systematic review and meta-analysis.

机构信息

Department of Neurology, The People's Hospital Affiliated to Ningbo University, Ningbo 315040, Zhejiang Province, China.

出版信息

Medicine (Baltimore). 2022 Aug 26;101(34):e30168. doi: 10.1097/MD.0000000000030168.

BACKGROUND

This systematic review evaluates the effect of exercise training in the treatment of patients with mild cognitive impairment (MCI).

METHODS

PubMed, Medline, EMBASE, Web of Science, and Cochrane Library databases were systematically searched up to Oct 2021 in order to identify randomized controlled trials (RCTs) which evaluated the effects of physical exercise in persons with MCI. Changes of cognitive and physical function were tested using pre- and postMMSE and TUG scores, and were compared with control intervention.

RESULTS

A total of 10 RCTs involving 635 MCI patients were included in the meta-analysis. Physical exercise improved MMSE scores (MD 0.71, 95 % CI 0.57 to 0.85, P < .00001, I2 = 95 %) and TUG performance (MD -0.82, 95 % CI -1.20 to -0.45, P < .00001, I2 = 12 %) in patients with MCI.

CONCLUSIONS

This meta-analysis demonstrated a positive effect of exercise training in people with MCI in relation to cognitive and physical function. These findings suggest exercise interventions be persistent, and reveal that more high-quality researches are needed.

背景

本系统评价评估了运动训练对轻度认知障碍（MCI）患者的治疗效果。

方法

系统检索了 PubMed、Medline、EMBASE、Web of Science 和 Cochrane Library 数据库，截至 2021 年 10 月，以确定评估运动对 MCI 患者影响的随机对照试验（RCT）。使用 MMSE 和 TUG 评分的前后变化来测试认知和身体功能的变化，并与对照组干预进行比较。

结果

共有 10 项 RCT 纳入了 635 名 MCI 患者进行荟萃分析。运动改善了 MCI 患者的 MMSE 评分（MD 0.71，95 % CI 0.57 至 0.85，P <.00001，I2 = 95 %）和 TUG 表现（MD -0.82，95 % CI -1.20 至 -0.45，P <.00001，I2 = 12 %）。