Momeni Sarieh, Ghorbani-Vaghei Ramin
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, Iran.
Department of Organic Chemistry, Faculty of Chemistry, Guilan University, Rasht, Iran.
Heliyon. 2024 Dec 12;11(1):e41149. doi: 10.1016/j.heliyon.2024.e41149. eCollection 2025 Jan 15.
This study introduces a new nano catalyst tailored for the eco-friendly synthesis of pyrido[2,3-]pyrimidine via a three-component one-pot reaction involving benzaldehydes, malononitrile, and uracil. To achieve this objective, we anchored copper acetate onto the surface of layered double hydroxides modified with 1,3‑benzenedisulfonyl amide (BDSA) (LDH@PTRMS@BDSA@Cu(NO)), which exhibited remarkable activity and selectivity. The main benefits of this method include high product yield, swift reaction times, straightforward purification, catalyst reusability, and the employment of a mild reaction process. Furthermore, the catalyst maintained its effectiveness even after being recycled four times without notable degradation in catalytic performance.
本研究介绍了一种新型纳米催化剂，该催化剂专为通过涉及苯甲醛、丙二腈和尿嘧啶的三组分一锅法反应，以环保方式合成吡啶并[2,3 - ]嘧啶而量身定制。为实现这一目标，我们将醋酸铜锚定在经1,3 - 苯二磺酰酰胺（BDSA）改性的层状双氢氧化物表面（LDH@PTRMS@BDSA@Cu(NO)），该催化剂表现出显著的活性和选择性。此方法的主要优点包括产品收率高、反应时间短、纯化简单、催化剂可重复使用以及采用温和的反应过程。此外，该催化剂即使在循环使用四次后仍保持有效性，催化性能无明显下降。
