Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Dental School Federal University of Bahia. Salvador, Bahia, Brazil.
Braz Dent J. 2022 Jul-Aug;33(4):97-102. doi: 10.1590/0103-6440202204711.
Hand-foot syndrome (HFS) is a common adverse effect of anticancer therapy. It is known to cause dermatological symptoms including acral erythema and dysesthesia of the palms and soles of the feet, swelling, pain, itching, and scaling. Some drugs, like capecitabine, are known to trigger this condition. However, pigmentation of the oral mucosa is a rare adverse effect. This study aims to report a case of oral mucosa hyperpigmentation caused by capecitabine therapy before the clinical diagnosis of HFS. A 58-year-old female, diagnosed with invasive breast duct carcinoma, had the central nervous system, liver, skin, and lung metastasis, using capecitabine every day for 14 cycles. Oral examination revealed multifocal black macules on the hard palate, bilateral buccal mucosa, gingival mucosa, and dorsum of the tongue. The clinical hypothesis was oral mucosa hyperpigmentation by capecitabine use and only periodic follow-up was necessary. Hyperpigmentation of oral mucosa by capecitabine is a rare consequence of neoplastic therapy and your association with HFS is unclear, and poorly reported. The report of these events is important to alert oncology health teams about the individual tolerance to capecitabine therapy.
手-足综合征（HFS）是癌症治疗的一种常见不良反应。它已知会引起皮肤病症状，包括手足的红斑和感觉异常、肿胀、疼痛、瘙痒和脱屑。一些药物，如卡培他滨，已知会引发这种情况。然而，口腔黏膜色素沉着是一种罕见的不良反应。本研究旨在报告一例由卡培他滨治疗引起的口腔黏膜过度色素沉着病例，该病例在 HFS 的临床诊断之前。一名 58 岁女性，诊断为浸润性乳腺导管癌，患有中枢神经系统、肝脏、皮肤和肺部转移，每天使用卡培他滨 14 个周期。口腔检查显示硬腭、双侧颊黏膜、牙龈黏膜和舌背有多发性黑斑。临床假设是卡培他滨引起的口腔黏膜色素沉着，只需定期随访。卡培他滨引起的口腔黏膜色素沉着是肿瘤治疗的罕见后果，与 HFS 的关联尚不清楚，也鲜有报道。报告这些事件对于提醒肿瘤学医疗团队注意卡培他滨治疗的个体耐受性非常重要。
