Lal Hina Shaikh
Department of Skin and Venereal Diseases, Goa Medical College, Bambolim, Goa, India.
Indian J Dermatol Venereol Leprol. 2014 Sep-Oct;80(5):427-30. doi: 10.4103/0378-6323.140302.
A 55-year-old woman on treatment with capecitabine and paclitaxel for breast carcinoma presented with history of a tingling sensation in her hands and feet with a progressive burning sensation. She also noted discomfort, minimal pain and stiffness while holding objects. On examination, there was patchy hyperpigmentation of both the palms and soles, and the dorsa of hands and feet. This was accompanied by a thickening of the skin more over the knuckles and toes. In addition there was a moist desquamation around the toes and over the palmar creases and a bluish discoloration of the lunulae of both thumbnails. She was diagnosed with hand and foot syndrome and started on pyridoxine and emollients. The finding of keratoderma noted in our patient is not seen commonly in hand and foot syndrome.
一名55岁女性因乳腺癌接受卡培他滨和紫杉醇治疗，出现手脚刺痛感，并伴有逐渐加重的烧灼感。她还提到在握持物品时感到不适、轻微疼痛和僵硬。检查发现，手掌、脚底以及手背和脚背均有片状色素沉着。指关节和脚趾处皮肤增厚。此外，脚趾周围、手掌褶皱处有湿性脱皮，双侧拇指甲半月痕呈蓝色。她被诊断为手足综合征，并开始服用吡哆醇和使用润肤剂。我们患者中发现的角化病在手足综合征中并不常见。
