Grebeniuk Dmytro, Nazarchuk Oleksandr, Dzis Nataliia, Taran Illia, Slyvka Elina, Abdullaiev Vahif, Bobyr Vitalii, Mashevska Oksana
National Pirogov Memorial Medical University, Vinnytsya.
Bohomolets National Medical University.
Acta Biomed. 2022 Aug 31;93(4):e2022275. doi: 10.23750/abm.v93i4.12461.
Bacterial vaginosis is among serious health problem for women of reproductive age which influences on their local changes in inflammatory mediators and quality of life. The aim was to assess the dependence of the dynamics of changes in the quality of life of patients with bacterial vaginosis on local levels of TNF-α and IL-1β.
In the prospective study 37 women aged 19-40 years with bacterial vaginosis were treated according to the Centers for Disease Control and Prevention. Patients received vaginal suppositories of clindamycin phosphate (100 mg) once daily for 3 days before bedtime. TNF-α, IL-1β levels in vaginal secretions by means of ELISA test), as well as the quality of life according to the RAND 36-Item Health Survey 1.0 were studied as in control group (once - to determine the reference values) and in the dynamics (the 1st day - before treatment, on the 7th day - after treatment) in the main group.
After the treatment microscopy of smears-imprints of vaginal secretions showed the complete absence of pathological microflora. The treatment was well tolerated by all patients. In the result there was proved the role of bacterial vaginosis in a violation of the quality of life of patients mainly due to the mental component of health, even after clinical and laboratory recovery.
There was proved the relation of vaginal TNF-α and IL-1β with physical and mental health in patients with bacterial vaginosis which can have a prognostic significance of the disease.
细菌性阴道病是育龄期女性面临的严重健康问题之一，会影响其局部炎症介质变化和生活质量。目的是评估细菌性阴道病患者生活质量变化动态与局部肿瘤坏死因子-α（TNF-α）和白细胞介素-1β（IL-1β）水平之间的相关性。
在这项前瞻性研究中，37名年龄在19至40岁之间的细菌性阴道病女性患者按照美国疾病控制与预防中心的方案进行治疗。患者在睡前每天一次接受克林霉素磷酸酯阴道栓剂（100毫克），共3天。通过酶联免疫吸附测定法（ELISA）检测阴道分泌物中的TNF-α、IL-1β水平，并按照兰德36项健康调查1.0评估生活质量，在对照组（一次 - 确定参考值）以及主要组的动态过程中（第1天 - 治疗前，第7天 - 治疗后）进行研究。
治疗后阴道分泌物涂片印记的显微镜检查显示完全没有病理性微生物群。所有患者对治疗耐受性良好。结果证明细菌性阴道病对患者生活质量的影响主要体现在健康的心理方面，即使在临床和实验室指标恢复之后。
已证实细菌性阴道病患者阴道中的TNF-α和IL-1β与身心健康有关，这对该疾病可能具有预后意义。
