Rastogi N, Henrotte J G, David H L
Zentralbl Bakteriol Mikrobiol Hyg A. 1987 Mar;263(4):548-51. doi: 10.1016/s0176-6724(87)80198-0.
Addition of 100 micrograms/ml of colistin (polymyxin E) to an actively-growing culture of Mycobacterium aurum caused apparent loss of viability starting after 20 min of drug addition, whereas significant Mg++ efflux was apparent within 5 min of drug addition. Therefore, Mg++ efflux preceded cell death by at least 15 min. These data confirmed earlier reports showing that colistin interacted with the cytoplasmic membrane of mycobacteria.
向活跃生长的金色分枝杆菌培养物中添加100微克/毫升的黏菌素（多黏菌素E），在添加药物20分钟后开始出现明显的活力丧失，而在添加药物5分钟内就明显出现大量镁离子外流。因此，镁离子外流比细胞死亡至少提前15分钟。这些数据证实了早期的报道，即黏菌素与分枝杆菌的细胞质膜相互作用。
