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长链非编码RNA HOXB-AS1是一种预后标志物，可促进肝癌细胞的增殖和侵袭。

Long non-coding RNA HOXB-AS1 is a prognostic marker and promotes hepatocellular carcinoma cells' proliferation and invasion.

作者信息

Chen Yubin, Wang Na, Cao Liangqi, Zhang Dawei, Peng Heping, Xue Ping

机构信息

Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Guangzhou Medical University, No. 63 Yayun South Road, Guangzhou, 510000, Guangdong Province, China.

出版信息

Open Life Sci. 2022 Aug 15;17(1):944-951. doi: 10.1515/biol-2022-0040. eCollection 2022.

DOI:10.1515/biol-2022-0040
PMID:36045719
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9380905/
Abstract

Long non-coding RNAs (lncRNAs) are broadly transcribed in the genome of human and play critical roles in the progression of multiple diseases. Long non-coding HOXB cluster antisense RNA 1 (HOXB-AS1) is a tumor exciter in various cancers. This study aimed to investigate the involvement of HOXB-AS1 in hepatocellular carcinoma (HCC). In the following study, HOXB-AS1 was unveiled to be highly expressed in HCC tissues as opposed to normal tissues. Silencing of HOXB-AS1 led to the loss of proliferation, migration, and invasiveness of HCC cells, namely Hep3B and Huh7. Moreover, the data showed that expression levels of HOXB-AS1 contribute significantly to the patient's survival rates. Otherwise, HOXB-AS1 levels in the serum of patients proved HOXB-AS1 as a biomarker for analysis and treatment of HCC. In summary, this study highlights HOXB-AS1 as key upregulated lncRNA in HCC which being an oncogene can cause proliferation and metastasis of HCC cells. The results also highlighted HOXB-AS1 as a promising biomarker for early diagnosis and prognosis of patients with HCC.

摘要

长链非编码RNA（lncRNAs）在人类基因组中广泛转录，并在多种疾病的进展中发挥关键作用。长链非编码HOXB簇反义RNA1（HOXB-AS1）在多种癌症中是一种肿瘤促进因子。本研究旨在探讨HOXB-AS1在肝细胞癌（HCC）中的作用。在接下来的研究中，发现HOXB-AS1在HCC组织中高表达，而在正常组织中低表达。沉默HOXB-AS1导致HCC细胞（即Hep3B和Huh7）的增殖、迁移和侵袭能力丧失。此外，数据表明HOXB-AS1的表达水平对患者的生存率有显著影响。此外，患者血清中的HOXB-AS1水平证明其可作为HCC分析和治疗的生物标志物。总之，本研究强调HOXB-AS1是HCC中关键的上调lncRNA，作为一种癌基因可导致HCC细胞的增殖和转移。研究结果还突出了HOXB-AS1作为HCC患者早期诊断和预后的有前景的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/64fd90d777c8/j_biol-2022-0040-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/6b9b184482d2/j_biol-2022-0040-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/91125403d221/j_biol-2022-0040-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/4dff040cdfed/j_biol-2022-0040-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/64fd90d777c8/j_biol-2022-0040-fig004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/6b9b184482d2/j_biol-2022-0040-fig001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/91125403d221/j_biol-2022-0040-fig002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/4dff040cdfed/j_biol-2022-0040-fig003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b24b/9380905/64fd90d777c8/j_biol-2022-0040-fig004.jpg

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Sunitinib increases the cancer stem cells and vasculogenic mimicry formation via modulating the lncRNA-ECVSR/ERβ/Hif2-α signaling.舒尼替尼通过调节 lncRNA-ECVSR/ERβ/Hif2-α 信号通路增加癌症干细胞和血管生成拟态形成。
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