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长链非编码 RNA HOXB-AS1 在子宫内膜癌中上调，并通过海绵吸附 miR-149-3p 来上调 Wnt10b。

Long Noncoding RNA HOXB-AS1 Is Upregulated in Endometrial Carcinoma and Sponged miR-149-3p to Upregulate Wnt10b.

机构信息

Department of Obstetrics and Gynecology, 85024Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Department of Orthopaedic Surgery, 85024Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

出版信息

Technol Cancer Res Treat. 2020 Jan-Dec;19:1533033820967462. doi: 10.1177/1533033820967462.

DOI:10.1177/1533033820967462
PMID:33073693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7592328/
Abstract

The functions of Long noncoding RNA (lncRNA) HOXB-AS1 have been investigated in glioblastoma and multiple myeloma. However, the role of lncRNA HOXB-AS1 in endometrial carcinoma (EC) remains largely unknown. This study investigated the underlying mechanisms of the lncRNA HOXB-AS1 on the progression of EC. In this study, We found that HOXB-AS1 expression was significantly upregulated in EC tissue samples and was associated with shorter survival time. Furthermore, upregulation of HOXB-AS1 promoted proliferation, invasion, and migration of EC cell. HOXB-AS1 and Wnt10b directly bound to miR-149-3p. HOXB-AS1 increased the expression of Wnt10b by binding to miR-149-3p. We further verified the upregulation of β-catenin, cyclin D1, and c-myc induced by HOXB-AS1. In conclusion, our results indicated that HOXB-AS1 exerted oncogenic function as competing endogenous RNA (ceRNA) of miR-149-3p to release Wnt10b and activated Wnt/β-catenin pathway.

摘要

长链非编码 RNA（lncRNA）HOXB-AS1 的功能已在神经胶质瘤和多发性骨髓瘤中进行了研究。然而，lncRNA HOXB-AS1 在子宫内膜癌（EC）中的作用在很大程度上尚不清楚。本研究探讨了 lncRNA HOXB-AS1 对 EC 进展的潜在机制。在这项研究中，我们发现 HOXB-AS1 在 EC 组织样本中的表达显著上调，并且与较短的生存时间有关。此外，HOXB-AS1 的上调促进了 EC 细胞的增殖、侵袭和迁移。HOXB-AS1 和 Wnt10b 直接与 miR-149-3p 结合。HOXB-AS1 通过与 miR-149-3p 结合增加了 Wnt10b 的表达。我们进一步验证了 HOXB-AS1 诱导的β-catenin、cyclin D1 和 c-myc 的上调。总之，我们的结果表明，HOXB-AS1 作为 miR-149-3p 的竞争性内源 RNA（ceRNA）发挥致癌功能，释放 Wnt10b 并激活 Wnt/β-catenin 通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/bb7c0ada9b9c/10.1177_1533033820967462-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/1848e71ae22e/10.1177_1533033820967462-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/a9597dd5f5fd/10.1177_1533033820967462-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/e1f46921cca2/10.1177_1533033820967462-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/c9dfffe7f8be/10.1177_1533033820967462-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/b9c7d1a50f07/10.1177_1533033820967462-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/bb7c0ada9b9c/10.1177_1533033820967462-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/1848e71ae22e/10.1177_1533033820967462-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/a9597dd5f5fd/10.1177_1533033820967462-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/e1f46921cca2/10.1177_1533033820967462-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/c9dfffe7f8be/10.1177_1533033820967462-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/b9c7d1a50f07/10.1177_1533033820967462-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/56af/7592328/bb7c0ada9b9c/10.1177_1533033820967462-fig6.jpg

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