混合阈值激光治疗糖尿病性黄斑水肿：一项单中心队列研究的回顾性分析
Hybrid threshold laser to treat diabetic macular edema: A retrospective analysis single center cohort study.
作者信息
Marashi Ameen, Zazo Aya
机构信息
Marashi Eye Clinic, Aleppo, Syria.
Faculty of Medicine, University of Aleppo, Aleppo, Syria.
出版信息
Ann Med Surg (Lond). 2022 Jul 31;80:104222. doi: 10.1016/j.amsu.2022.104222. eCollection 2022 Aug.
BACKGROUND
Diabetic patients suffers from reduction of vision that one of its main causes is clinically significant macular edema (CSME).The purpose of this study to determine if hybrid threshold can reduce macular thickness in Diabetic Macular Edema.
MATERIALS AND METHODS
This study is a retrospective analysis single center cohort study. 12 eyes in 10 patients diagnosed with diabetic macular edema using SD-OCT treated with Hybridthreshold laser as the leaking microaneurysms were treated with threshold laser on the 5% duty cycle settings.A complete fundus exam, including best-corrected visual acuity changes, and monthly measuring retinal thickness using SD-OCT for 24 weeks follow up.
RESULTS
Reduction of retinal thickness from 336.58 ± 86.26 μm to 264.33 ± 61.41 μm (p = 0.02) at 24 weeks follow up without significant changes of best-corrected visual acuity from 0.16 LogMAR to 0.08 LogMAR (p = 0.2) with minimal scar formation in 24 weeks follow up.
CONCLUSION
532 nm Hybridthreshold laser reduces macular thickness up to 20% and stabilizes diabetic macular edema for 24 weeks follow up.
背景
糖尿病患者存在视力下降的情况，其主要原因之一是具有临床意义的黄斑水肿（CSME）。本研究的目的是确定混合阈值激光是否能降低糖尿病性黄斑水肿患者的黄斑厚度。
材料与方法
本研究为单中心队列回顾性分析。10例诊断为糖尿病性黄斑水肿的患者共12只眼，使用SD - OCT进行检查，对于渗漏的微动脉瘤，采用混合阈值激光治疗，阈值激光设置为5%的占空比。进行完整的眼底检查，包括最佳矫正视力变化，并在24周的随访期内每月使用SD - OCT测量视网膜厚度。
结果
随访24周时，视网膜厚度从336.58±86.26μm降至264.33±61.41μm（p = 0.02），最佳矫正视力从0.16 LogMAR变化至0.08 LogMAR，无显著变化（p = 0.2），且在24周随访期内瘢痕形成极少。
结论
532nm混合阈值激光可使黄斑厚度降低达20%，并在24周的随访期内稳定糖尿病性黄斑水肿。
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