De Rosa Viviana, Fonti Rosa, Vecchio Silvana Del, Iommelli Francesca
Institute of Biostructures and Bioimaging, National Research Council, 80145 Naples, Italy.
Department of Advanced Biomedical Sciences, University "Federico II", 80131 Naples, Italy.
Explor Target Antitumor Ther. 2021;2(1):36-47. doi: 10.37349/etat.2021.00032. Epub 2021 Feb 28.
The occurrence of phenotype switch from an epithelial to a mesenchymal cell state during the activation of the epithelial mesenchymal transition (EMT) program in cancer cells has been closely associated with the generation of invasive tumor cells that contribute to metastatic dissemination and treatment failure. Liquid biopsy represents an emergent non-invasive tool that may improve our understanding of the molecular events leading to cancer progression and initiating the metastatic cascade through the dynamic analysis of tumor-derived components isolated from body fluids. The present review will primarily focus on the applications of liquid biopsy in lung cancer patients for identifying EMT signature, elucidating molecular mechanisms underlying the acquisition of an invasive phenotype and detecting new targets for therapy.
在癌细胞中上皮-间质转化（EMT）程序激活期间，从上皮细胞状态到间质细胞状态的表型转换的发生与侵袭性肿瘤细胞的产生密切相关，这些侵袭性肿瘤细胞会导致转移扩散和治疗失败。液体活检是一种新兴的非侵入性工具，通过对从体液中分离出的肿瘤衍生成分进行动态分析，可能会增进我们对导致癌症进展和启动转移级联反应的分子事件的理解。本综述将主要关注液体活检在肺癌患者中的应用，用于识别EMT特征、阐明获得侵袭性表型的潜在分子机制以及检测新的治疗靶点。
